Effectiveness of Vitamin D in Primary Dysmenorrhoea

An excessive uterine production of prostaglandins is the pathogenic trigger of dysmenorrhoea. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the currently accepted drugs for the management of this disorder. The capacity for synthesizing vitamin D and the presence of vitamin D receptor in human cycling endometrium have also been demonstrated. Because vitamin D reduces the synthesis of prostaglandins, a beneficial effect of vitamin D for the uterus is possible.Vitamin E inhibits the release of arachidonic acid and the conversion of arachidonic acid to prostaglandin via an action on the enzymes phospholipase A2 and cyclooxygenase.

Inclusion criteria

• Women had regular menstrual cycles lasted 21 to 35 days, with menstruation lasting 3 to 7 days;
• Women had to be in good health and taking no medications including calcium, magnesium, vitamin D and oral contraceptives.
• Women had not a previous history of gynaecological disease, and a normal pelvic examination were eligible.

Exclusion criteria

• Previous and current use of intrauterine contraceptive devices within the 6 months to enrollment was not permitted