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Completed

NCT Number: NCT06885658

Effectiveness of Visual Storytelling Intervention on Antibiotic Adherence in UTI Patients

This study aims to evaluate the effectiveness of a visual storytelling intervention in improving antibiotic adherence among adults with urinary tract infections (UTIs). Participants will be randomly assigned to either the intervention group, where they will receive a visual sticker on their antibiotic packaing, explaining the importance of completing their antibiotic course, or the control group, which will receive routine care. The study will measure how well participants follow their prescribed antibiotic regimens and assess their knowledge and attitudes toward antibiotic use. The goal is to determine if visual storytelling can enhance adherence, reduce antibiotic resistance, and improve health outcomes.

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Key information

Conditions

Uncomplicated Urinary Tract Infection Patient With Uncomplicated UTI

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Tertiary care hospitals (n = 6)

Peshawar, Khyber Pakhtunkhwa, Pakistan

About this study

This randomized controlled trial (RCT) will assess the impact of a visual storytelling intervention on antibiotic adherence among adults diagnosed with uncomplicated urinary tract infections (UTIs). The intervention involves a visually engaging sticker that educates patients on the importance of completing their prescribed antibiotic course and the consequences of non-adherence, such as antibiotic resistance. Participants will be randomly assigned to either the intervention or control group, with the control group receiving standard care (e.g., verbal or written instructions). The primary outcome is adherence to the antibiotic regimen, measured by pill counts. Secondary outcomes include UTI recurrence, knowledge about antibiotic use, and attitudes toward antibiotic treatment. Data will be collected at baseline, immediately after the intervention, and at follow-up visits over 1, 3, and 6 months. This study seeks to determine if visual storytelling can improve antibiotic adherence and help combat antibiotic resistance.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 18 years or older.
  • Physician-confirmed diagnosis of uncomplicated urinary tract infection (UTI).
  • Prescribed oral antibiotics (tablet/capsule) for UTI treatment.
  • Willingness to participate in the study and provide informed consent.
  • Ability to complete follow-up assessments and adhere to the study protocol.

Exclusion criteria

  • Diagnosed with complicated UTI (e.g., pyelonephritis, sepsis, or structural abnormalities).
  • Multiple comorbidities that require polypharmacy.
  • Cognitive impairment or mental disorders that would interfere with study participation.
  • Pregnant or breastfeeding women.
  • Participation in another clinical trial that could interfere with this study.

Treatment and study plan

Visual Storytelling Intervention for Antibiotic Adherence

Behavioral

The intervention involves the use of a visual storytelling approach designed to improve antibiotic adherence in patients diagnosed with urinary tract infections (UTIs). The intervention consists of a sticker featuring simple, visually appealing illustrations and a narrative highlighting the importance of completing the full course of prescribed antibiotics. The story contrasts the positive outcomes of adhering to the treatment with the negative consequences of stopping early, such as increased bacterial resistance. Key messages are reinforced through bold text and visual cues. This intervention aims to engage patients emotionally and cognitively, promoting behavior change by making the concept of antibiotic adherence more relatable and memorable.

Primary outcomes

  1. Antibiotic adherence

    Time frame: Based on the antibiotic treatment course (3-7 days)

    The primary outcome measure of this study is antibiotic adherence, which will be assessed by tracking the number of prescribed antibiotic pills taken by the participants at the end of their treatment course (typically 3-7 days).

    Adherence will be calculated in two ways:

    Proportional Adherence: The percentage of the prescribed pills that the patient takes will be calculated, expressed as a proportion (number of pills taken/total prescribed).

    Categorical Adherence: Patients will be categorized as "adhered" (if they took ≥90% of the prescribed antibiotics) or "not adhered" (if they took <90% of the prescribed antibiotics).

Secondary outcomes

  1. UTI Recurrence

    Time frame: UTI recurrence will be assessed at 3 months, and 6 months following the initial antibiotic treatment.

    This outcome will assess whether a participant experiences a recurrence of a urinary tract infection (UTI) after completing the prescribed course of antibiotics. Recurrence will be confirmed by a physician based on clinical evaluation and/or laboratory tests. A binary response (Yes/No) will be recorded based on physician confirmation of UTI recurrence.

  2. Knowledge

    Time frame: Knowledge will be assessed at baseline (before the intervention) and at first follow up (3-7 days) 3 months, and 6 months follow-up after the intervention.

    Knowledge Measurement: A 10-item true/false questionnaire will assess the patient's understanding of antibiotic use, antibiotic resistance, and the importance of completing the full antibiotic course. This includes questions like understanding the consequences of not completing antibiotic treatment or misusing antibiotics.

  3. Attitude

    Time frame: Attitude will be assessed at baseline (before the intervention) and at first follow up (3-7 days) 3 months, and 6 months follow-up after the intervention.

    Attitude Measurement: A 5-item Likert scale will assess the patient's attitude towards antibiotics and adherence. Statements such as "Completing the full course of antibiotics is very important" and "I trust the advice given by my doctor regarding antibiotics" will be used to gauge attitude.

Sponsors and collaborators

Lead sponsor

Xi'an Jiaotong University

Other

Registry information

Official study title

Effectiveness of Visual Storytelling Intervention on Antibiotic Adherence in UTI Patients in Pakistan: a Randomized Controlled Trial

Acronym: ABR UTI

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
Mar 20, 2025
Registry last updated
Apr 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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