Effectiveness of Transcranial Magnetic Stimulation (TMS) in Smoking Cessation, Combining Withdrawal Stimulation Followed by Maintenance Stimulation to Prevent Relapse.

Inclusion criteria

• Patient who has given oral consent
• Adult patient
• Patient wishing to stop smoking
• Patient highly addicted to nicotine (≥ score 7 on Fagerström's self-questionnaire*)
• Patient with at least 1 previous smoking cessation failure using recommended drug therapies (nicotine, vareniciline, bupropion)

Exclusion criteria

• Patient not affiliated or not benefiting from national health insurance
• Person deprived of their liberty by judicial or administrative decision
• Protected adults (curatorship, guardianship)
• Pregnant, parturient or breastfeeding woman
• Patient of childbearing age with a positive pregnancy test at inclusion
• Major patient incapable or unable to express consent
• Patient abstinent in the previous 3 months
• Patient with a substance use disorder (DSM-5 criteria) with other psychoactive substances other than tobacco
• Patient with a contraindication to the practice of TCS; personal history of seizure, pacemaker, neurosurgical clips, carotid or aortic clips, heart valves, hearing aid, ventricular bypass valve, sutures with wires or staples, foreign bodies in the eye, shrapnel, other prosthesis or cephalic ferromagnetic material.
• Patient employed by the investigator or trial site
• Patient with severe depression, defined by a score greater than or equal to 24 on the Hamilton Depression Rating Scale
• Patient who has had a recent change (< 1 month) in the prescription of psychotropic treatment
• Patient with severe and/or chronic psychiatric disorders, including schizophrenia, paranoia, and bipolar disorders type I and II.
• Patient with severe heart, kidney, liver or lung failure or other condition that the physician believes may compromise the patient's participation in the study.
• Patient simultaneously participating in another therapeutic trial