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NCT Number: NCT07483190

Effectiveness of Thoracoabdominal Nerve Block (M-TAPA) on Postoperative Pain Relief in Laparoscopic Hysterectomy

This study aims to investigate the effectiveness of a specific regional anesthesia technique, the Modified-Thoracoabdominal Nerve Block through a Perichondrial Approach (M-TAPA), on reducing pain after laparoscopic hysterectomy surgery. Hysterectomy is a common major surgical procedure, and managing postoperative pain is crucial for patient comfort and faster recovery.

Participants will be randomly assigned to one of two groups:

The M-TAPA Group: Patients will receive the nerve block using a local anesthetic (bupivacaine) before the surgery begins.

The Control Group: Patients will receive standard postoperative pain management without the nerve block.

The primary goal is to determine if the M-TAPA block reduces the total amount of opioid (morphine) used by patients in the first 24 hours after surgery. The researchers will also evaluate pain scores (NRS), the time until the first request for additional pain medication, patient satisfaction, and any side effects like nausea or vomiting

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Key information

Conditions

Postoperative Pain Hysterectomy Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Plane Blocks Postoperative Complications Signs and Symptoms

Age range

18 year–70 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Istinye University Liv Hospital Bahcesehir

Istanbul, Turkey (Türkiye)

Location status: Recruiting

Location contact

onur senyurt

CONTACT

[email protected]

+905520265992

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged between 18 and 70 years
  • ASA (American Society of Anesthesiologists) physical status I, II, or III
  • Scheduled for elective laparoscopic hysterectomy
  • Voluntary participation with signed informed consent

Exclusion criteria

  • Hepatic or renal disease.
  • Coagulation disorders.
  • Uncontrolled cardiovascular or respiratory diseases.
  • Psychiatric disorders.
  • History of allergy to local anesthetics.
  • History of alcoholism, drug or substance abuse.
  • Body Mass Index (BMI) greater than 35 kg/m2
  • Refusal of the regional block procedure

Treatment and study plan

Modified-Thoracoabdominal Nerve Block through a Perichondrial Approach (M-TAPA)

Procedure

Under ultrasound guidance, a 22-gauge peripheral block needle is inserted at the costochondral angle (9th-10th ribs). After confirming the position, 20 ml of 0.25% bupivacaine is injected bilaterally into the lower part of the chondrium.

Primary outcomes

  1. Morphine consumption

    Time frame: First 24 hours postoperatively

    Total amount of morphine (mg) used via Patient-Controlled Analgesia (PCA)

Secondary outcomes

  1. Postoperative Pain Scores (NRS)

    Time frame: Baseline (Hour 0), 1, 2, 4, 6, 12, and 24 hours postoperatively

    Numerical Rating Scale (0=no pain, 10=worst pain)

  2. Rescue analgesic drug consumption

    Time frame: Within the first 24 hours postoperatively

    The amount of rescue analgesic in mg required by the patient will be recorded for the first 24 hours.

  3. Incidence of postoperative nausea and vomiting

    Time frame: Within the first 24 hours postoperatively

    Number of patients developing postoperative nausea and vomiting will be recorded for the first 24 hours

Study contacts

Contact information is provided by the study sponsor or research team.

onur senyurt

CONTACT

[email protected]

+905520265992

Sponsors and collaborators

Lead sponsor

Istinye University

Other

Registry information

Official study title

Effectiveness of Modified-Thoracoabdominal Nerve Block With Perichondrial Approach (M-TAPA) on Postoperative Pain Relief in Laparoscopic Hysterectomy Surgery: A Prospective, Randomized, Double-Blind, Controlled Study

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Mar 19, 2026
Registry last updated
Jun 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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