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OpenTrials
Completed

NCT Number: NCT05725616

Effectiveness of the Anatomical Snuff Box Approach for Coronary Angiography

The main objective of the study is to assess whether the distal radial arterial approach (snuff box or back of the hand) is not inferior to the radial arterial approach at the wrist, in the management of coronary angiography for diagnostic purposes

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Cardiologie Tonkin

Villeurbanne, 69100, France

About this study

Coronary angiography is the reference examination for anatomical exploration coronary arteries to determine the presence or absence of a predominantly obstructive coronary disease.

Historically, the femoral approach was the most common approach used in interventional cardiology. The radial approach to the forearm presents multiple advantages over the femoral route, and it became the gold standard approach to coronary angiography and intervention percutaneous coronary. Although uncommon, vascular complications related to the radial pathway exist.

This is why a more distal radial approach, above the long tendon extensor of the thumb (at the level of the anatomical snuff box) or downstream (at the back of the hand) was suggested more than 10 years ago. This pathway is now an advantageous alternative to the radial approach of first intention, both for the patient and for the practitioner.

The two procedures are common today but few studies have been developed to compare the two approaches. Therefore, the main objective of the study is to assess whether the distal radial arterial approach (snuff box or back of the hand) is not inferior to the radial arterial approach at the wrist, in the management of coronary angiography for diagnostic purposes

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient, male or female, aged 18 and over
  • Patient having a diagnostic coronary angiography programmed by radial route.
  • Patient with a radial pulse at the anatomical snuff box and at the wrist noticeable

Exclusion criteria

  • Patient requiring emergency coronary angiography or having an acute coronary syndrome
  • Patient with severe arteriopathy of the supra-aortic trunks
  • Patient with a history of coronary bypass surgery
  • Tall patients (>1.90m)
  • Patient allergic to xylocaine
  • Patient presenting a contraindication to the realization of a coronary angiography:

terminal IRC, pregnancy, severe sepsis....

Treatment and study plan

Coronary Angiography

Procedure

Snuff Box Approach or radial Arterial Approach at wrist for coronary angiography.

Primary outcomes

  1. Success rate of coronary angiography without changing puncture route.

    Time frame: 1 day

    The primary endpoint is the success rate of coronary angiography without changing puncture route.

Sponsors and collaborators

Lead sponsor

GCS Ramsay Santé pour l'Enseignement et la Recherche

Other

Registry information

Official study title

Effectiveness of the Anatomical Snuff Box Approach for Coronary Angiography: Comparative Non-inferiority Study With the Radial Arterial Approach to the Wrist

Acronym: COROTAB

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Feb 13, 2023
Registry last updated
Nov 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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