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NCT Number: NCT05480410

Effectiveness of rTMS on Pain and Quality of Life in Patients With Cancer Neuropathic Pain. Clinical Trial.

The purpose of this study is to evaluate the effectiveness of Repetitive transcranial magnetic stimulation (rTMS) on pain and quality of life in patients with cancer neuropathic pain.

Although there are currently different therapeutic options for neuropathic pain, most are limited or restricted to pharmacotherapy. Transcranial magnetic stimulation (TMS) is a tool recently incorporated into neuroscience in the management of neuropathic cancer pain.

The study will include 10 patients with oncologic neuropathic pain who will receive 20 sessions of rTMS and the effect on pain and quality of life.

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Key information

Conditions

Neuropathic Pain Neoplasms Nervous System Diseases Neuralgia Neurologic Manifestations Neuromuscular Diseases Pain Pathological Conditions, Signs and Symptoms Peripheral Nervous System Diseases Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CORTEX

Medellín, Antioquia, 055421, Colombia

About this study

Neuropathic pain is defined as pain caused by a primary lesion or transient dysfunction of the central or peripheral nervous system. In cancer, it is generated as a consequence of multiple factors such as: direct compression of nerve structures, post-surgical nerve injuries, and nerve injuries secondary to chemotherapy. At least 3.5 million people around the world suffer from this symptom associated with cancer; Of this population, 38% experience pain in all stages and 80% in advanced stages, negatively impacting quality of life.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with neuropathic pain of oncological origin
  • Patients of legal age (18 years old)
  • Patients using their cognitive faculties

Exclusion criteria

  • Pregnancy
  • History of negative reaction to TMS
  • History of seizure, history of epilepsy stroke, brain surgery and cranial metal implants.

Treatment and study plan

repetitive transcranial magnetic stimulation

Device

rTMS is a minimal invasive technique which focus on the M1 cortex. It can stimulate the cortex by depolarizing superficial neurons. For this study we will use a MagVenture MagPro R20

Other names: rTMS

Primary outcomes

  1. Effect of Change of 20 rTMS Sessions on Pain

    Time frame: Day 1 vs Day 20 vs 1st month follow up and vs 3rd month follow up

    Assessment of pain quantify by Visual analogue scale rated from 0-10, where 0 is the least pain and 10 the worst pain

  2. Effect of Change of 20 rTMS Sessions on Pain and Functionality

    Time frame: Day 1 vs Day 20 vs 1st month follow up and vs 3th month follow up

    Assessment of pain severity and functionality quantify by brief pain inventory from 0-10, where 0 is the least pain and 10 the worst pain

Secondary outcomes

  1. Effect of Change of 20 rTMS Sessions on Quality of Life

    Time frame: Day 1 vs Day 20 vs 1st month follow up and vs 3rd month follow up

    Assessment of Quality of life, measured by Functional Assessment of cancer Therapy (FACT-GOG- NTX 13) (0-100) higher number means a better quality of life

Sponsors and collaborators

Lead sponsor

Fundacion Universitaria Maria Cano

Other

Registry information

Official study title

Effectiveness of Repetitive Transcranial Magnetic Stimulation (rTMS) on Pain and Quality of Life in Patients With Cancer Neuropathic Pain. Clinical Trial

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Jul 29, 2022
Registry last updated
Jun 6, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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