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OpenTrials
Completed

NCT Number: NCT02310893

Effectiveness of Peer Navigation and Contingency Management on Retention in HIV Care

Consistent treatment with anti-retroviral therapy (ART) suppresses viral load (VL), prolonging life and improving quality of life for HIV+ persons. Suppressing VL benefits communities by reducing transmission to others. Mere availability of ART and care, however, is insufficient; the benefits of ART depend upon HIV+ persons' continuous visits to the health care provider, regular monitoring and regular delivery of medications, - known as retention in HIV care. In spite of national efforts, up to a quarter of HIV+ persons, especially low-income minorities are out of care. Innovative interventions are therefore urgently needed to maximize engagement and retention in HIV care, self-reported adherence, as well as HIV-1 RNA viral load suppression. In pursuit of these aims, the proposed study will assess outcomes of the following interventions in comparison to usual care: 1) contingency management (CM) only; 2) peer navigation (PN) only; and 3) a combined approach that integrates both CM and PN (CA) which the investigators hypothesize to be most effective in improving HIV clinical outcomes.

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Key information

Conditions

HIV/AIDS Acquired Immunodeficiency Syndrome Blood-Borne Infections Communicable Diseases Genital Diseases HIV Infections Immune System Diseases Immunologic Deficiency Syndromes Infections Lentivirus Infections RNA Virus Infections Retroviridae Infections Sexually Transmitted Diseases Sexually Transmitted Diseases, Viral Slow Virus Diseases Urogenital Diseases Virus Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

AltaMed Health Services Corporation, Los Angeles, California, United States

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosed HIV+
  • Age 18 years or older
  • English or Spanish speaking
  • Residence in Los Angeles County
  • prescribed ART in prior 24 months
  • < 3 visits in prior 12 months or have detectable viral load, as identified in the Ryan White CaseWatch database

Exclusion criteria

Not meeting any of the criteria identified above

Treatment and study plan

Combined Contingency Management and Peer Navigation

Behavioral

Contingency Management

Behavioral

Peer navigation

Behavioral

Primary outcomes

  1. Change in retention-in-care behaviors over 12 months

    Time frame: Basline, follow-ups at month 2, 6, 12

    Using a 2x2 factorial design, to examine the effect of the three interventions -- peer navigation, contingency management, combined approach and usual care -- and evaluate how well they improve retention in HIV care

  2. Change in HIV RNA viral load suppression and medication adherence over 12 months

    Time frame: Basline, follow-ups at month 2, and 12

    Using the same design, to examine the effects of the PN, CM and, CA interventions on HIV RNA viral load suppression and self-reported adherence

Secondary outcomes

  1. Cost effectiveness

    Time frame: 5 years

    A secondary aim is to examine the cost-offset and potential cost-effectiveness of each intervention compared with usual care

Sponsors and collaborators

Lead sponsor

University of California, Los Angeles

Other

Registry information

Acronym: CHAMPS

Important dates

Study start
2016
Primary completion
2019
Study completion
2020
First posted
Dec 8, 2014
Registry last updated
Nov 17, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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