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NCT Number: NCT07695181

Effectiveness of Pain Neuroscience Education Along With Neural Mobilization Versus Neural Mobilization Alone on Pain, Functional Disability And Quality of Life In Patients With Diabetic Neuropathic Pain

This is a randomized controlled trial aims to evaluate the comparative effect of Pain Neuroscience Education combined with neural mobilization versus neural mobilization alone in patients with diabetic neuropathic pain. This study will Compare pain intensity between intervention groups and assess functional disability outcomes. Furthermore, this will evaluate changes in quality of life and to analyze pain-related beliefs following PNE.

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Key information

Conditions

Diabetic Neuropathic Pain

Age range

40 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age ≥ 40 years (WHO 2016 criteria) Diagnosed Type II diabetes mellitus Lower limb neuropathic pain ≥ 3 months Pain intensity ≥ 4/10 on NPRS Able to walk independently and follow instructions

Exclusion criteria

Neurological disorders (e.g. stroke, Guillain-Barré) Lumbar disc herniation with radiculopathy Lower limb surgery or spinal fracture within 6 months Active diabetic foot ulcer Diagnosed cognitive impairment or severe infection

Treatment and study plan

Pain Neurosciences Education + Neural Mobilization

Other

In Group A pain neuroscience Education will be given in adjunct with neural mobilization techniques Target nerves: Sciatic, tibial & common peroneal Technique: Slider neurodynamic mobilization Dosage: 10-15 reps × 2-3 sets | Rest: 30-60 sec between sets Session duration: 15-20 minutes PNE: 20-30 min (weeks 1-2) → 10 min reinforcement (weeks 3-6) Methods: Simple diagrams, patient-friendly metaphors, video demonstrations

Primary outcomes

  1. Pain intensity

    Time frame: Baseline to week 6

    Pain intensity will be evaluated using Numeric Pain Rating Scale

  2. Functional disability

    Time frame: Baseline to week 6

    Functional disability will be evaluated using Urdu version of Lower Extremity Functional Scale (LEFS)

  3. Quality of life

    Time frame: Baseline to week 6

    Quality of life will be evaluated by World Health Organization Quality Of Life-BREF

  4. Central sensitization

    Time frame: Baseline to week 6

    Central sensitization will be evaluated using Central Sensitization Inventory

Study contacts

Contact information is provided by the study sponsor or research team.

Roshan Farman, MSPT

CONTACT

[email protected]

+923188108470

Somiya Naz, PhD scholar

CONTACT

[email protected]

+923315163093

Sponsors and collaborators

Lead sponsor

Ibadat International University, Islamabad

Other

Registry information

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Jul 10, 2026
Registry last updated
Jul 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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