Effectiveness of Oleanolic Acid as Intracanal Medicament on Infectious/Inflammatory Contents in Teeth With Apical Periodontitis

The objective of this study is to investigate "clinically" the effectiveness of Oleanolic acid based intracanal medicament compared to the commonly used intracanal medicaments (Calcium hydroxide and Ledermix) on the levels of bacteria in root canals and inflammatory cytokines in the periradicular tissues of teeth with apical periodontitis.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Intracanal Medicaments Endodotic Microbiota Inflammatory Cytokines

Age range

20 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Mansoura University

Al Mansurah, Dakahlia Governorate, 35511, Egypt

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Single rooted teeth with pulp necrosis and apical periodontitis.
The age ranges from 20 to 60 years.

Exclusion criteria

Patient receiving antibiotic treatment within the preceding 3 months.
Patient reporting systemic disease.
Teeth that can not be isolated with rubber dam.
Teeth with periodontal pockets deeper than 3 mm.

Treatment and study plan

Root canal treatment

Procedure

Root canal treatments with administration of intracanal medicaments

Primary outcomes

Relief of signs and symptoms of apical periodontitis

Time frame: 1 Week

Absence of discomfort with percussion, Absence of inflammatory exudate from the root canal.
Decrease in bacterial count within the root canal.

Time frame: 1 week

A sample will be taken from the canal to assess the decrease in bacterial count inside the root canal by the effect of intracanal medicament.
Decrease in interleukin TNF-alpha, IL-1 Beta and PG-E2 in the periapical tissues

Time frame: 1 week

A sample will be taken from the periapical region to detect the effect of the intracanal medicaments in reducing inflammation and promoting healing in the periapical region.

Sponsors and collaborators

Lead sponsor

Mansoura University

Other

Registry information

Important dates

Study start: 2026
Primary completion: 2026
Study completion: 2026
First posted: Apr 16, 2026
Registry last updated: Apr 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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