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Completed

NCT Number: NCT04560504

Effectiveness of Oculomotor Training in Parkinson's Disease

Parkinson's disease (PD) is a common neurodegenerative disorder which is characterized by both motor and non-motor symptoms and usually affects people aged 50 years or above. Many studies showed eye movement deficits and visual changes in patients with PD.

Previous studies have also indicated that clinical eye movement training could enhance the functional performance of patients with various eye movement problems resulting from ocular and neurodegenerative diseases.

In this study, we will investigate the effectiveness of eye movement training on dynamic vision and functional performance in PD patients with oculomotor deficits.

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Key information

Conditions

Parkinson Disease Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Movement Disorders Nervous System Diseases Neurodegenerative Diseases Oculomotor; Disorder Parkinsonian Disorders Synucleinopathies

Age range

40 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Allen MY Cheong

Hong Kong

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Parkinson's Disease diagnosed by a neurologist or geriatrician with the range of Stage

1 to 4 (Hoehn and Yahr Classification)

  • Able to speak and comprehend Cantonese dialect
  • Able to travel independently

Exclusion criteria

  • Any congenital eye problem (e.g. congenital strabismus or amblyopia in either eye) or any manifest eye diseases (e.g. macular degeneration, glaucoma, etc)
  • Severe medical problems (e.g. stroke)
  • Cognitive impairment (e.g. dementia)
  • Presence of any psychiatric or neurological diseases (apart from Parkinson's disease) or receiving of any psychoactive pharmacological treatment
  • Receiving any medication that is known to affect eye movement and cognitive function
  • Previous formal vision rehabilitation or oculomotor intervention

Treatment and study plan

Control Group

Other

Leisure activities

Oculomotor Training Group

Other

Eye movement training

Primary outcomes

  1. Smooth Vergence eye movements

    Time frame: Change from baseline at week 4 and change from baseline at week 12

    Smooth vergence eye movement is measured using a head-mounted eye tracking while fixating at an approaching target moving at different speeds

Secondary outcomes

  1. Oculomotor characteristics

    Time frame: Change from baseline at week 4 and change from baseline at week 12

    With the use of eye tracking device, eye movement behavior of participants can be measured and analysed while performing the following tasks.

    • Fixation task - Fixate at stationary target presented on a monitor
    • Saccade task - Follow and fixate at a random jumping target presented on a monitor
    • Pursuit task - Follow accurately and steadily on a smooth moving target presented on a monitor
    • Jump Vergence task - Follow and fixate a jumping target presented in the anterior-posterior plane (jumping from 'far to near' or 'near to far')

  2. Sentence reading performance

    Time frame: Change from baseline at week 4 and change from baseline at week 12

    To evaluate the effectiveness of the interventions on sentence reading using MNREAD charts in Chinese. These charts developed in our laboratory are used to measure the effectiveness of sentence reading in terms of reading speed and critical print size.

  3. Passage reading performance

    Time frame: Change from baseline at week 4 and change from baseline at week 12

    To evaluate the effectiveness of the interventions on passage reading using International Reading speed Test (IReST). IReST is used to evaluate the effectiveness of passage reading performance by measuring the reading speed.

Sponsors and collaborators

Lead sponsor

The Hong Kong Polytechnic University

Other

Collaborators

  • Chinese University of Hong Kong
  • Deakin University
  • Hospital Authority, Hong Kong
  • University of California, Berkeley

Registry information

Official study title

Oculomotor Deficits in Parkinson's Disease: Enhancing Eye Movement Performance and Dynamic Visual Acuity With Oculomotor Training Using a Pilot Randomized Clinical Trial Design

Important dates

Study start
2020
Primary completion
2022
Study completion
2022
First posted
Sep 23, 2020
Registry last updated
Oct 29, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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