Effectiveness of Non-hormonal Treatment on Moderate to Severe Premenstrual Syndrome

A double-blind, randomised, placebo-controlled, parallel trial was conducted involving 100 females aged 18-40, all of whom presented with premenstrual syndrome at the Department of Gynecology and Obstetrics, Avicenna Medical College Hospital, Lahore, Pakistan. Participants were randomly assigned to two groups of equal size: One group received vitamin D supplementation at a dose of 50,000 IU every two weeks along with a daily intake of 1,000 mg of calcium, whereas the comparison group was administered a placebo under the same conditions for 12 weeks. All the participants were examined on premenstrual syndrome with the Premenstrual Symptoms Screening Tool-Adolescent (PSST-A) questionnaire

Inclusion criteria

• Participants aged 18-40 years with moderate to severe PMS

Exclusion criteria

• Individuals exhibiting symptoms of malnutrition or requiring calcium+vitamin D supplementation.
• Individuals with systemic diseases such as sepsis, hemodynamic instability, or acute meningitis; diarrhoea.
• Individuals with known intolerance or sensitivity to calcium vitamin D or calcium vitamin D containing compounds.
• smokers, Individuals with exposure to stressful situations or a history of mental illness.