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NCT Number: NCT07351604

Effectiveness of Large Language Model-Based Chatbot Among Female University Stdents in Improving HPV Vaccine Awareness, Intention and Vaccination Rates

This is an interventional study targeting female university students. The primary objective of the study is to evaluate the effectiveness of a vaccine chatbot in improving HPV vaccination rates. The secondary objectives are to evaluate the effectiveness in improving vaccine awareness and vaccination intention. All participants will be enrolled and randomly assigned to four groups: (1) vaccine chatbot plus scientific videos, (2) vaccine chatbot only, (3) scientific videos only, and (4) a control group (no intervention). The chatbot will provide immediate, validated answers to participants' HPV vaccine-related questions. The scientific videos will cover content related to HPV vaccine safety, efficacy, and other relevant information. The study will compare changes in HPV vaccine awareness, vaccination intention, and vaccination behavior between the intervention groups and the control group after the intervention to evaluate whether the three intervention strategies enhance HPV vaccine awareness, vaccination intention, and vaccination uptake.

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Key information

Conditions

HPV Vaccination Rates HPV Vaccination Intention HPV Vaccine Awareness

Age range

15 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Female university students.
  • Possess an electronic device with QR code scanning capability.
  • Female university students have no contraindications to HPV vaccination.
  • No mental disorders or visual/reading impairments; able to cooperate with and implement the corresponding intervention activities.
  • Have provided informed consent and are willing to participate in the study.

Exclusion criteria

-

Treatment and study plan

Scientific videos

Device

Provide scientific videos related to HPV vaccine

Vaccine chatbot

Device

Provide vaccine chatbot to answer HPV vaccine questions

Primary outcomes

  1. HPV vaccination rates for female university students in all groups before and after the intervention

    Time frame: Baseline and two months

    Whether female university students get vaccinated against HPV or have an appointment for vaccination, measured by self-report and validated by vaccination information system

Secondary outcomes

  1. HPV vaccine awareness for eligible female university students in all groups before and after the intervention

    Time frame: Baseline and two weeks

    A questionnaire consisting of 11 questions related to HPV vaccines will be used to investigate the awareness of HPV vaccines.Total knowledge score is calculated based on the number of questions answered correctly by the participants and the higher scores mean a better outcome.

  2. HPV vaccination intention for eligible female university students in all groups before and after the intervention

    Time frame: Baseline and two weeks

    Female university students' willingness to vaccinate themselves, measured using a five-point Likert scale from "not willing at all" to "strongly willing"

Other outcomes

  1. Vaccine chatbot acceptability and implementability

    Time frame: Two weeks

    A questionnaire consisting of 10 questions assessing usability and feasibility, fairness and safety, user experience, and overall assessment of the chatbot, measured using a five-point Likert scale from "not willing at all" to "strongly willing"

  2. Factors influencing vaccination intention for eligible female university students

    Time frame: Two weeks and six months

    Survey items: age, education level, marital status, occupation, annual income, and awareness of vaccines.

  3. HPV vaccination rates for female university students in all groups after the intervention

    Time frame: two weeks, one month and six months

    Whether female university students get vaccinated against HPV or have an appointment for vaccination, measured by self-report and validated by vaccination information system

Sponsors and collaborators

Lead sponsor

Xiamen University

Other

Registry information

Official study title

A Study on the Effectiveness of Large Language Model-Based Chatbot Interventions Among Female University Stdents in Improving HPV Vaccine Awareness, Intention and Vaccination Rates

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Jan 20, 2026
Registry last updated
Mar 31, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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