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Completed

NCT Number: NCT07106619

Effectiveness of Isokinetic Exercises in Proprioception for Post-stroke Patients

Somatosensory dysfunction including the sense of movement and position, i.e. proprioception, is observed in approximately 65% of patients after stroke. Loss of muscle strength, especially in the lower extremities, and impaired proprioception lead to significant loss of function in stroke patients. In addition, recent studies have emphasised that sensory information obtained by target-oriented exercises plays an important role in neuroplasticity and proprioception is an important element. The aim of this study was to evaluate the effect of knee isokinetic muscle strengthening exercises on proprioception and balance in stroke patients.

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Key information

Conditions

Stroke Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Nervous System Diseases Vascular Diseases

Age range

35 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Ankara Etlik City Hospital

Ankara, Yenimahalle, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • At least 3 months and no more than 1 year must have passed since the date of the incident
  • Be between 35 and 75 years of age
  • Manual muscle testing of the affected lower extremity shows at least 3 in ankle dorsiflexion and knee extension
  • No limitation in passive joint range of motion in the lower extremity
  • Mini mental test score > 23

Exclusion criteria

  • Presence of spasticity according to the modified Ashworth scale > 1+
  • Presence of neurological disease other than stroke
  • Presence of other medical conditions that may cause sensorimotor dysfunction in the lower extremities (e.g., diabetic polyneuropathy)
  • Presence of orthopaedic problems affecting lower extremity function
  • Previous history of stroke or ischaemic attack
  • Poor general health status (e.g. severe heart failure, COPD)

Treatment and study plan

Isokinetic Exercises

Device

Exercises will be performed at three different angular speeds (90 ̊/sec, 5 repetitions, 5 sets; 120 ̊/sec, 8 repetitions, 5 sets; 150 ̊/sec, 10 repetitions, 5 sets).

conventional rehabilitation program

Other

Ambulation and balance exercises

Primary outcomes

  1. Proprioception assessment with isokinetic test device

    Time frame: before treatment and at the 3rd week of treatment

Secondary outcomes

  1. Berg scale

    Time frame: Before treatment and at 3rd week of treatment

  2. Time up and Go Test

    Time frame: Before treatment and at the 3rd week of treatment

Sponsors and collaborators

Lead sponsor

Ankara Etlik City Hospital

Other Gov

Registry information

Official study title

Evaluation of the Effect of Knee Isokinetic Strengthening Exercises on Proprioception and Balance in Stroke Patients

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Aug 6, 2025
Registry last updated
Jul 14, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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