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Completed

NCT Number: NCT03808363

Effectiveness of High Intensity Interval Training (HIIT) on Improving Cardiometabolic Health After SCI

Testing the efficacy of high intensity interval training (HIIT), as compared to current research supporting moderate intensity continuous training (MICT), as a means to improve cardiometabolic health after spinal cord injury.

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Key information

Conditions

Metabolic Syndrome Cardiovascular Diseases Central Nervous System Diseases Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Metabolic Diseases Nervous System Diseases Nutritional and Metabolic Diseases Spinal Cord Diseases Spinal Cord Injuries Trauma, Nervous System Wounds and Injuries

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Brock University

Saint Catherines, Ontario, Canada

About this study

This study aims to challenge the effectiveness of the current aerobic exercise recommendations for individuals with spinal cord injuries (SCI). Currently, moderate intensity continuous training (MICT) is suggested however this study intends to explore the effectiveness of high intensity interval training (HIIT). To do so, approximately 8 individuals with SCI will be undergo a 6 week HIIT intervention consisting of 3 sessions per week. With a focus on cardiometabolic health markers (listed in outcome measure section), we aim to provide support for HIIT as a viable method of mitigating cardiovascular risk in a SCI population.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Individuals with a spinal cord injury (paraplegia or tetraplegia, complete or incomplete) who are at least one-year post injury.
  • Declared medically stable, and able to communicate clearly in English.

Treatment and study plan

High Intensity Interval Training

Other

Participants assigned to this group will perform a very mild 5-minute warm-up (0 resistance, and 60 rpm), followed by 5 one-minute bouts of high intensity exercise, with 90 seconds between each bout. These bouts will be followed by a 3-minute cool down (0 resistance, and 60 rpm). The high-intensity exercise will be performed at an intensity of 17 on the Borg rating of perceived exertion (RPE) scale (very hard), and the 90 second active rest intervals will be performed at an intensity of 7-9 (very, very light - very light). The exercise will be performed on the NuStep machine 3 times a week for 6 weeks.

Other names: HIIT

Primary outcomes

  1. Waist circumference (inches)

    Time frame: 6 weeks

    Central adiposity will be measured by tape measure to monitor possible weight loss

  2. Cholesterol

    Time frame: 6 weeks

    Total and HDL cholesterol will be measured in serum

  3. Triglycerides

    Time frame: 6 weeks

    Triglycerides will be measured in serum

  4. Glycated Hemoglobin (HbA1c)

    Time frame: 6 weeks

    Glycated hemoglobin will be measured in whole blood as an indicator of diabetic risk

  5. Tumor necrosis factor (TNF-a)

    Time frame: 6 weeks

    TNF-a will be used as an inflammatory representative and will be measured in serum

  6. Interleukin - 10 (IL-10)

    Time frame: 6 weeks

    IL-10 will will be used as an anti-inflammatory representative and will be measured in serum

  7. Pulse Wave Velocity

    Time frame: 6 weeks

    Arterial stiffness, a common measure for cardiac risk will be measured

  8. Blood pressure

    Time frame: 6 weeks

    Measured through a digital cuff, the focus will be on both systolic and diastolic

  9. Peak Oxygen Consumption (VO2 peak)

    Time frame: 6 weeks

    VO2 peak will be measured by a Moxus metabolic cart to determine changes in fitness

  10. C Reactive Protein (CRP)

    Time frame: 6 weeks

    CRP will will be used as an inflammatory representative and will be measured in serum

  11. Leptin

    Time frame: 6 weeks

    Leptin will will be used as a body fat representative and will be measured in serum

  12. Adiponectin

    Time frame: 6 weeks

    Adiponectin will will be used as a surrogate for insulin resistance and will be measured in serum

Secondary outcomes

  1. Physical Activity Enjoyment Scale (PACES)

    Time frame: 6 weeks

    All participants will complete the physical activity enjoyment scale (PACES) to indicate enjoyment of HIIT. With a total of 18 questions, options 1 through 7 going from a positive to a negative overall experience with the HIIT protocol will be documented.

Sponsors and collaborators

Lead sponsor

Brock University

Other

Registry information

Official study title

High-intensity Interval Training Versus Moderate Intensity Continuous Training as a Means to Improve Cardiometabolic Health After Spinal Cord Injury

Important dates

Study start
2019
Primary completion
2019
Study completion
2019
First posted
Jan 17, 2019
Registry last updated
Jan 18, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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