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Completed

NCT Number: NCT06947785

Effectiveness of Combined Neural Mobilization With Manual Myofascial Release for Sciatic Pain Relief

This study will address to evaluate and compare both Neural mobilization and Manual Myofascial Release of piriformis and Lumbar muscles in sciatic pain with the aim of evaluating and identifying the most effective intervention for managing this specific condition, and provide valuable insights into the effectiveness, mechanisms, and practical considerations associated with these interventions, ultimately contributing to evidence based and patient centered care.

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Key information

Conditions

Sciatica Mononeuropathies Nervous System Diseases Neuralgia Neurologic Manifestations Neuromuscular Diseases Pain Pathological Conditions, Signs and Symptoms Peripheral Nervous System Diseases Sciatic Neuropathy Signs and Symptoms

Age range

20 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Riphah International University, Malakand

Chakdara, KPK, 18800, Pakistan

About this study

MFR is a hands-on technique targeting fascial restrictions that may contribute to pain and reduced mobility. Barnes proposed that releasing fascial adhesions can improve circulation, reduce nerve compression, and enhance tissue flexibility. In a study by Ajimsha et al. , MFR was found to significantly reduce pain and improve physical function in patients with nonspecific low back pain. There is a lack of comparative research assessing the relative efficacy of neural mobilization andMFR in sciatic pain management. While both techniques are rooted in distinct mechanisms neural desensitization versus fascial release they may have overlapping benefits in improving mobility and reducing pain. This study addresses this research gap by directly comparing the two approaches in individuals with sciatic pain.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinically diagnosed unilateral sciatic pain for >3 months.
  • Positive Straight Leg Raise (SLR).

Exclusion criteria

  • Participants fall in this category would be excluded of the study.
  • Recent spinal surgery or trauma.
  • Neurological deficits or systemic conditions affecting the nervous system.
  • Any other red flags

Treatment and study plan

Combined Neural Mobilization with Manual myofascial Release

Other

Combined neural mobilization with manual myofascial release will be provided to each subject.

Other names: Neural Mobilization, Manual Myofascial Release

Neural Mobilization

Other

neural mobilization will be provided to each subject.

Other names: Combined Neural Mobilization with Manual myofascial Release, Manual Myofascial Release

Manual myofascial release

Other

Manual myofascial release will be provided to each subject.

Other names: Combined Neural Mobilization with Manual myofascial Release, Neural Mobilization

Primary outcomes

  1. Numerical pain rating scale

    Time frame: Four Weeks

    A subjective pain assessment tool where patients rate their pain intensity on a scale from 0 (no pain) to 10 (worst imaginable pain).

  2. Universal Goniometer

    Time frame: Four Weeks

    Joint range of motion will be measured using a Universal Goniometer in degrees (°). Each joint movement will be assessed individually. The goniometer will be used following standardized procedures as per the American Academy of Orthopaedic Surgeons (AAOS) guidelines. Unit of Measure is degrees.

  3. Patient-Specific Functional Scale

    Time frame: Four Weeks

    The Patient-Specific Functional Scale is a validated patient-reported outcome measure used to assess functional limitations based on activities identified by the patient. Participants will rate their ability to perform 3-5 self-selected activities that are important to them, using an 11-point scale ranging from 0 to 10.

    Minimum score: 0 (indicating the patient is unable to perform the activity)

    Maximum score: 10 (indicating the patient can perform the activity at their prior level with no difficulty)

    Interpretation: Higher scores indicate better functional status.

    The average score across all selected activities will be used for analysis.

  4. SLR (Straight Leg Raise)

    Time frame: Four Weeks

    A clinical test used to assess sciatic nerve irritation or lumbar radiculopathy by raising the extended leg while the patient lies supine.

Sponsors and collaborators

Lead sponsor

Riphah International University

Other

Registry information

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Apr 27, 2025
Registry last updated
Apr 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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