Effectiveness of Cannabidiol vs. Narcotics for Post Operative Pain Control in Elective Shoulder Arthroscopic Surgery

This study is a prospective, randomized, nonblinded trial to evaluate the effectiveness of Cannabidiol (CBD) oil on post-operative pain control compared to opioid medications.

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Key information

Conditions

Post-operative Pain Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Primary location

Florida Orthopaedic Institute

Tampa, Florida, 33736, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age 18 years or older
Requiring shoulder arthroscopic surgery for soft tissue pathology
Able to complete surveys and follow-up visits

Exclusion criteria

Younger than 18 years of age
Shoulder dislocation, fracture, previous surgery, coexisting extremity pathology, pregnancy.

Treatment and study plan

Cannabidiol Oil

Drug

Subjects will self-administer CBD sublingually.

Primary outcomes

Post-operative pain

Time frame: 30 days post-operatively

Numerical Pain Scale (NRS): 0 being no pain, 10 being the worst pain imaginable. Higher scores are worse outcomes.

Secondary outcomes

Sleep Quality

Time frame: 30 days preoperatively leading up to surgery then 30 days postoperatively as well. Outcomes will be collected from surgery to 6 weeks postoperatively.

Insomnia Severity Index

Sponsors and collaborators

Lead sponsor

Foundation for Orthopaedic Research and Education

Other

Registry information

Acronym: CBDS

Important dates

Study start: 2022
Primary completion: 2024
Study completion: 2024
First posted: Feb 15, 2022
Registry last updated: Mar 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed