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OpenTrials
Completed

NCT Number: NCT00237861

Effectiveness of Atypical Versus Conventional Antipsychotics in Treating Schizophrenia

This study will compare the effectiveness of newer atypical antipsychotics versus older conventional antipsychotics in treating schizophrenia.

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Key information

Conditions

Schizophrenia Mental Disorders Schizophrenia Spectrum and Other Psychotic Disorders

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

About this study

At seven participating hospitals, acutely exacerbated patients with schizophrenia were randomly assigned to treatment with antipsychotic from the atypical class vs antipsychotic from the conventional class. Medication choice within class, dose, concomitant medications, and other prescribing decisions were left to the community prescriber. Patients were followed for one year after discharge.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • hospitalized for schizophrenia

Exclusion criteria

  • none

Treatment and study plan

Risperidone

Drug

Olanzapine

Drug

Quetiapine

Drug

Primary outcomes

  1. PANSS

  2. Retention.

Secondary outcomes

  1. EPS, TD.

Sponsors and collaborators

Lead sponsor

Yale University

Other

Collaborators

  • National Institute of Mental Health (NIMH)

Registry information

Official study title

Effectiveness of Atypical Vs Conventional Antipsychotics

Important dates

Primary completion
2002
First posted
Oct 12, 2005
Registry last updated
Jun 6, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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