Effectiveness of a Procedure for Previously Failed Glaucoma Surgery

Transconjunctival mitomycin-C in needle bleb revision may be an effective procedure to treat cases with a previously failed trabeculectomy. We will investigate approximately 100 consecutive cases with follow up of up to 9 years. We anticipate that this procedure is an effective, safe, and appropriate option for successful glaucoma treatment.

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Key information

Conditions

Glaucoma Eye Diseases Ocular Hypertension

Age range

0 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Glaucoma Center of San Francisco

San Francisco, California, 94105, United States

About this study

The healing process after filtering surgery for glaucoma may cause an unsuccessful outcome for the trabeculectomy procedure. In order to control the rising intraocular pressure due to the failed trabeculectomy, medications may be restarted and/or filtering surgery may need to be repeated. Our primary research showed that transconjunctival mitomycin-C in needle bleb revision may be an effective procedure to control this situation.

This retrospective study will follow over 100 patients from May 1997 to May 2006. This long-term follow up will help assess the future role of this technique in glaucoma practices.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Diagnosis of glaucoma
Failed filtering procedures- defined as intraocular pressure exceeded target pressure thus inducing possible further optic nerve damage

Exclusion criteria

Needling combined with other ocular surgical or laser treatments

Treatment and study plan

Glaucoma surgery- Bleb revision

Procedure

Sponsors and collaborators

Lead sponsor

Glaucoma Research & Education Group

Other

Collaborators

PharmaLogic Development, Inc.

Registry information

Official study title

Efficacy of Transconjunctival Mitomycin-C in Needle Revisions of Failing Trabeculectomy

Important dates

Study start: 1997
Study completion: 2006
First posted: Jul 4, 2006
Registry last updated: Jul 4, 2006

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed