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OpenTrials
Completed

NCT Number: NCT04124822

Effectiveness if Premedication With Single Dose Piroxicam and Prednisolone After a Single Visit Root Canal Treatment .

Two drugs (Piroxicam and Prednisolone)are being compared for post operative endodontic pain after a single visit root canal treatment for 74 hours.

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Key information

Conditions

Post-operative Endodontic Pain

Age range

20 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2 / Phase 3

Primary location

DUHS

Karachi, Sindh, 75500, Pakistan

About this study

To evaluate effectiveness of single dose premedication with piroxicam(20mg) and prednisolone(20mg) on post endodontic pain after a single visit root canal treatment .

patient will be recalled every day for 4 days to know the pain scale using visual analogue scale .

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient ages from 20-40 years(28).
  • Single rooted tooth with symptomatic irreversible pulpitis.
  • With no analgesic or anti-inflammatory drug taken within a week period before procedure.

Exclusion criteria

  • Patients presenting with any systemic disease
  • Patients already taking premedication for endodontic pain.
  • Pregnant or lactating patients.
  • Multirooted teeth.
  • Teeth with Pulpal necrosis.
  • Previously treated or initiated root canal treatment.
  • Patient presenting with allergy due to drug

Treatment and study plan

Piroxicam 20 mg

Drug

Piroxicm is from oxicam family of anti inflammatory drug that inhibits prostaglandin synthesis and effectively lower pain threshold levels

prednisolone 20 mg

Drug

prednisolone is from steroid family of anti inflammatory drug that inhibit arachidonic acid and effectively lowers the pain

Primary outcomes

  1. post operative pain

    Time frame: 76 hours

    post operative pain will be measured after single visit endodontic treatment using visual analog scale with readings 1 to 10 from 24 hours till 76 hours

Sponsors and collaborators

Lead sponsor

Dow University of Health Sciences

Other

Registry information

Official study title

Effectiveness of Single Dose Pre Medication of Piroxicam and Prednisolone on Post Endodontic Pain After a One Visit Root Canal Treatment. Randomized Trial .

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Oct 11, 2019
Registry last updated
Oct 11, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.