Effectiveness and Safety of Zingiber Officinale Transdermal Patch for Acne Vulgaris; Study of Interleukin 1 and Skin Microbiome

Current acne vulgaris treatment include antibiotic, retinoic acid, and benzoyl peroxide. The use of antibiotic has been linked to antibiotic resistant problem. Research also has shown the association between acne vulgaris and skin microbiome. Therefore, new treatment for acne vulgaris that has good effect on skin microbiome is needed.

Z. officinale is an herb that commonly used in traditional medicine. Researches have shown that it has anti-inflammation activity and antibiotic activity to Cutibacterium acnes. On the other hand, the prebiotic potency of Z. officinale on gut microbiome has also been investigated.

This randomized controlled trial shall include 26 mild to moderate acne vulgaris patients according to inclusion and exclusion criteria. Patches will be given every 5 days as researcher follow up patient condition. Patient photograph will be taken before treatment, on follow up day, and after 21 days treatment. Skin microbiome specimen will be collected using skin swab method. Secret from a chosen pustule will be collected for interleukin examination.

During clinical trial, patient will use non comedogenic sunscreen and soap from researcher. Patient will be asked to report to researcher if there is side effect of treatment.

Inclusion criteria

• female
• 15-45 years old
• mild to moderate acne vulgaris according to Lehmann criteria
• minimal 3 pustules on face that are distributed on right and left sides

Exclusion criteria

• history of allergy to ingredients that is used in research
• history of topical acne medication and steroid in the last 2 weeks
• history of medical aesthetic procedure such as laser and chemical peeling in the last 2 weeks
• history of oral antibiotic therapy in the last 6 weeks
• history of oral isotretinoin therapy in the last 6 months
• history of probiotic consumption in the last 3 weeks
• pregnancy and lactation