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OpenTrials
Completed

NCT Number: NCT00217048

Effect of Yohimbine on Colon Transit

This study is being done to learn if yohimbine, a naturally occurring drug, affects the speed at which food travels through the stomach, intestines and colon, and if yohimbine affects the amount of liquid you can drink in a short period of time. Understanding how yohimbine works on the gut may help develop new treatments for patients with constipation. Yohimbine has been approved by the Food and Drug Administration (FDA) for routine clinical use, however, its use as proposed in this study is considered investigational.

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Key information

Conditions

Healthy Volunteers

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1 / Phase 2

Primary location

Mayo Clinic

Rochester, Minnesota, 55902, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

  • Healthy male or non-pregnant, non-breastfeeding female volunteers, -18-65 years old;
  • Able to provide written informed consent before participating in the study;
  • Able to communicate adequately with the investigator and to comply with the requirements for the entire study.

Treatment and study plan

Yohimbine, oral

Drug

Primary outcomes

  1. Colonic transit

Secondary outcomes

  1. Small bowel transit time

  2. Gastric emptying time

  3. Maximum tolerated volume ingested during satiation testing

  4. Average stools per day

  5. Stool consistency

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Collaborators

  • National Institutes of Health (NIH)

Registry information

Official study title

Effect of Oral Yohimbine on Colonic Transit: Randomized, Placebo-Controlled Trial

Important dates

Study start
2005
Primary completion
2005
Study completion
2005
First posted
Sep 22, 2005
Registry last updated
Apr 29, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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