Effect of Wheat Dextrin on Calcium and Magnesium Absorption

To compare calcium and magnesium absorption within subjects with and without chronic consumption of wheat dextrin.

Completed

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Key information

Conditions

Colonic Inertia Constipation Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Digestive

Age range

19 year and older

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Subjects will be generally healthy Caucasian females aged 19 and older with no known abnormalities of gastrointestinal function, and taking no medications that might alter absorptive performance. BMI will be between 19 and 31 kg/m2

Treatment and study plan

wheat dextrin

Dietary Supplement

5 grams of wheat dextrin baked in cookies will be taken 3 times a day for 2 weeks

Placebo

Dietary Supplement

cookies not containing wheat dextrin will be taken 3 times a day for 2 weeks

Primary outcomes

Calcium Absorption

Time frame: within 2-4 weeks

The calcium load to be tested will be 300 mg calcium from calcium and vitamin D fortified TropicanaTM orange juice extrinsically labeled with ≈3-7 μCi of 45Ca. The labeled orange juice will be ingested as part of a light meal, served as breakfast, after an overnight fast.

Secondary outcomes

Magnesium absorption

Time frame: within 2-4 weeks

The magnesium load to be tested will be from calcium and vitamin D fortified TropicanaTM orange juice extrinsically labeled with 30 mg 26Mg. The labeled orange juice will be ingested as part of a light meal, served as breakfast, after an overnight fast.

Sponsors and collaborators

Lead sponsor

Creighton University

Other

Collaborators

Novartis

Registry information

Acronym: Benefiber

Important dates

Study start: 2009
Primary completion: 2010
Study completion: 2010
First posted: Oct 29, 2010
Registry last updated: Oct 29, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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