Effect of Walking on Brain Fuel Consumption in Mild Alzheimer's Disease

The aim of this study is to evaluate the effect of a 3-month walking program on brain energy metabolism in patient with mild Alzheimer's disease (AD). Two groups of sedentary patients with mild AD are followed and compared over a 3-month period of time: Control (non-active) and walking (from 15 to 45 minutes of exercise on a treadmill, 3 times a week for 12 weeks) groups. All the participants are evaluated on their cognition, brain volumes (MRI) and brain fuel consumption (PET scan with 18-FDG and 11C-AcAc) at the beginning and at the end of the study.

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Key information

Conditions

Alzheimer's Disease Alzheimer Disease Brain Diseases Central Nervous System Diseases Dementia Mental Disorders Nervous System Diseases Neurocognitive Disorders Neurodegenerative Diseases Tauopathies

Age range

40 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Research Centre on Aging (CSSS-IUGS - CIUSSS de l'Estrie - CHUS)

Sherbrooke, Quebec, J1H4C4, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Diagnosis of mild Alzheimer's disease (NINCDS-ADRDA criteria)
Taking cholinesterase inhibitors
Sedentary
Ability to do physical exercise

Exclusion criteria

Parkinson disease
Down syndrome
Epilepsy or concussion
Drug or alcohol abuse
Past psychiatric history
Vitamin B12 Deficiency
Uncontrolled diabetes or thyroid function

Treatment and study plan

Physical exercise

Other

A 3-month walking program (3 times a week for 12 weeks) on treadmill supervised by a physiotherapist. Duration of the exercise is progressively increased from 15 min to 45 min over a 6-week period and the intensity of the exercise is moderate (a 12-13 score on Borg scale).

Primary outcomes

Brain Glucose Consumption

Time frame: 3 months

Brain glucose uptake (umol/100g/min) using 18F-FDG PET imaging
Brain Acetoacetate Consumption

Time frame: 3 months

Brain acetoacetate uptake (umol/100g/min) using 11C-AcAc PET imaging

Sponsors and collaborators

Lead sponsor

Université de Sherbrooke

Other

Registry information

Official study title

Evaluating the Impact of Physical Exercise on Mild Alzheimer's Disease in a Randomized Clinical Trial: Quantification With 18F -FDG and 11C- AcAc PET Imaging

Acronym: MAL

Important dates

Study start: 2009
Primary completion: 2017
Study completion: 2017
First posted: Mar 15, 2016
Registry last updated: Oct 16, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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