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NCT Number: NCT07065877

Effect of Vitamin D on Crestal Bone Loss Around Immediate Implant After Mandibular Premolars and Molars Extraction

What is the difference between grafting the jumping gap upon using xenograft mixed with topical vitamin D clinically regarding crestal bone level and implant stability, radiographically regarding crestal bone level after implant insertion in the posterior region of mandible?

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Key information

Conditions

Age range

20 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

oral and maxillofacial surgery depertment of oral and dental medicine faculty Suez canal university

Ismailia, Egypt

About this study

Effect of Vitamin D on Bone Regeneration .Vitamin D is known for its role in the skeletal system. Vit D deficiency is also widely researched for its effects on the healing of fractures, bone defects and osseointegration of implants. There are studies that investigated the effects of dietary supplementation with vitamin D to reduce vitamin D deficiency but increasing the serum level of this vitamin takes time therefore, an attempt has been made to combat the effect of vitamin D deficiency through topical application. up to the knowledge, upon search of literatures, there is not enough studies that correlate topical application of vitamin D with xenograft mixture as filling space material. this study is to Assess immediate implant with topical vitamin D and xenograft mixture clinically and Radiographically.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • The American Society of Anesthesiologist (ASA) I , II
  • Both Genders. 3- Patients having unrestorable tooth on the posterior mandibular region
  • Age>20
  • The patient who have complete their facial growth and teeth eruption
  • No bone disease or lesion in propose implant site

Exclusion criteria

  • Poor oral hygiene patients and/or patients
  • Patients with active acute infection.
  • Patients with bad oral habits.
  • Pregnant or lactating women.
  • Heavy smokers.
  • Alcohol and drug addicts.
  • Diabetes disease

Treatment and study plan

vit D mixed with xenograft

Drug

Topical application of vitamin D solution mixed with xenograft in the jumping gap around immediate implant

Other names: cholecalciferol

only xenograft without vit D

Drug

grafting the jumping gap with xenograft only around immediate implant

Other names: xenotransplant

Primary outcomes

  1. clinically: A)Loss of crestal bone. B)Stability of implant. Radiographically: crestal bone loss by periapical radiograph in millimeters.

    Time frame: clinically: Loss of crestal bone by periodontal prop assessed in millimeters in six months Stability of implant by OSTTEL assessed as ISQ values in six months crestal bone loss in millimeters will be one ,three months and six months.

    the loss of crestal bone after implant insertion using periodontal probe in millimeters.

    implant stability using OSTELL device. Postoperative follow up using periapical radiographs to evaluate crestal bone loss in millimeters will be after, one ,three months and six months by standardized parallel periapical digital technique radiograph .The radiographs will be done by using: The Kavo Scan eXamTM One and the Rinn extension cone paralleling (XCP)periapical film holder will be used to achieve standardization of digital radiographs.

Study contacts

Contact information is provided by the study sponsor or research team.

Mohamed Nageh Gad El-Hak, Lecturer

CONTACT

+201002061808

mohamed elsaeed ibrahim, master

CONTACT

[email protected]

+201150315750

Sponsors and collaborators

Lead sponsor

Suez Canal University

Other

Registry information

Official study title

Clinical and Radiographic Assessment Of Immediate Implant With Topical Vitamin D and Xenograft Mixture: A Randomized Controlled Study

Acronym: vitD

Important dates

Study start
2025
Primary completion
2026
Study completion
2027
First posted
Jul 15, 2025
Registry last updated
Jul 15, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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