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OpenTrials
Completed

NCT Number: NCT02298738

Effect of Vit D on New-onset AF in Hypertension

Atrial fibrillation (AF), an important cause of cardiac mortality and morbidity is the most common type of cardiac arrhythmia in clinical practice. Hypertensive individuals are at particular risk of development of atrial fibrillation. Renin-angiotensin-aldosteron system (RAS) which is activated in hypertension may be the underlying mechanism of AF among hypertensive patients.

Vitamin D deficiency has been shown to be involved in the pathogenesis of hypertension, cardiovascular disease and obesity. Increased RAS activity is one of the postulated mechanisms by which vitamin D deficiency may trigger the development of hypertension and various cardiovascular diseases. On the basis of these data we hypothesized that hypovitaminosis D might be associated with new-onset AF among patients with hypertension.

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Key information

Conditions

Atrial Fibrillation Arrhythmias, Cardiac Cardiovascular Diseases Heart Diseases Hypertension Pathologic Processes Pathological Conditions, Signs and Symptoms Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Hypertensive patients with new-onset AF

Exclusion criteria

Established coronary artery disease

  • Heart failure
  • Chronic obstructive pulmonary disease
  • Diabetes mellitus
  • Significant heart valve disease
  • Hyperthyroidism
  • Renal failure
  • Any malignancy
  • Acute infection
  • Recent thoracic or abdominal surgery
  • Under therapy of Vit D3

Treatment and study plan

Primary outcomes

  1. hypovitaminosis D

    Time frame: Baseline

    Identifying whether hypovitaminosis D is a risk factor for development of new-onset AF among hypertensive patients

Sponsors and collaborators

Lead sponsor

Ankara University

Other

Registry information

Official study title

Relation of Low Vitamin D Levels and New-onset AF Among Hypertensive Patients

Important dates

Study start
2012
Primary completion
2014
Study completion
2014
First posted
Nov 24, 2014
Registry last updated
Nov 24, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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