Effect of Virtual Reality on Depression… | Clinical Trial

Key information

Conditions

Depression Behavior Behavioral Symptoms

Age range

13 year–18 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

About this study

Depression is most commonly found in adolescents and large percentage of them don't receive management.

People with depression usually experience at least five of the following 9 characteristics: (1) people feel sad and unhappy; (2) have less interest in doing things; (3) individuals do not follow a diet, but their weight losses are obvious; (4) their appetites change and their weight may increase; (5) they suffer insomnia or drowsiness; (6) some people have mental agitation; (7) they feel that life is meaningless, or they feel guilty; (8) they have difficulty concentrating; or (9) they have suicidal thoughts . Individuals who develop depression may have experienced an anxiety disorder earlier in life.

Depression is most commonly found in adolescents and large percentage of them don't receive management The application of emerging technology in health promotion has generated substantial public interest. Among the emerging technologies that may potentially aid in the treatment of depression, virtual reality (VR) is the most exciting and technologically-advanced.

A virtual environment provides a greater degree of control for the therapists to customize, reproduce, and tweak several treatment parameters according to the patient's needs.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adolescent females suffer from depression who are diagnosed and referred by the psychiatrist.
Their ages will range from 13-18 years old
Their BMI will range from 15.5 -24.9 kg/m2
They are interested in their mental state or with depressive disorders and their score on Beck depression inventory (BDI) between 11-30 (mild to moderate depression)
They are interested in using VR technology to improve mental health problems.

Exclusion criteria

Patients who suffer from major diseases other than depression.
Adolescents who are not interested in VR.
Patients with severe mental illness or repetitive suicidal trials .
Patients who receive any other psychotherapy.
Obese patients with BMI more than 26.2 -29.5kg/m2

Treatment and study plan

Virtual Reality Headset

Device

Participants will use virtual reality glasses during treatment sessions for approximately 30 minutes per session, once per week for 8 weeks .

Selective serotonin reuptake inhibitors(SSRIs)

Drug

All adolescent females in the control group will receive antidepressant drugs Selective serotonin reuptake inhibitors(SSRIs) for 8 weeks as described by the psychiatrist

Primary outcomes

1-Calculation the score of Beck Depression Inventory [BDI] to assess the severity of depression.

Time frame: 8 weeks

Beck depression scale assess depression levels in both groups (A&B) before and after the end of the study. It is a self-administered questionnaire containing 21 items which takes about five minutes to be complete.

Patients will be asked to complete the questionnaire, add up the score for each of the twenty-one questions by counting the number to the right of each question she marked. The highest possible total for the whole test is sixty-three this mean patient circled number three on all twenty-one questions, the lowest possible score for each question is zero, this mean she circled zero on each question
2-Calculation the score of KIDSCREEN-52 questionnaire to assess the quality of life

Time frame: 8 weeks

KIDSCREEN-52 questionnairet consists of 52 itemes that can measure the following 10 dimensions: Physical Well-Being (5 items), Psychological Well-Being (6 items), Moods and Emotions (7 items),Self-Perception (5 items), Autonomy (5 items),Parent Relations and Home Life (6 items), Financial Resources (3 items), Peers and Social Support (6 items),School Environment (6 items) and social acceptance( Bullying) (3 items). It has high validity and reliability. Patients will be asked to complete the questionnaire,scores are computed for each dimension and are transformed into T-values with a mean of 50 and a standard deviation of 10; a low score indicates a poor QOL and higher score indicates higher QOL and wellbeing

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Important dates

Study start: 2026
Primary completion: 2027
Study completion: 2027
First posted: Mar 5, 2026
Registry last updated: Mar 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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