Effect of Vericiguat on Acute Coronary Syndrome( ACS）Patients With Ejection Fraction <45%

Vericiguat, a novel soluble guanylate cyclase stimulator, reduced the incidence of cardiovascular death or hospitalization for HF in a population of high-risk patients with heart failure with reduced ejection fraction （HFrEF ）who had recently been hospitalized or received intravenous diuretic therapy.Given the increasing incidence of patients with ACS and its challenges posing to life，investigators intend to conduct a prospective observational study. Investigators choose several meaningful endpoints including the time of cardiovascular death or heart failure（HF) hospitalization、inflammatory markers、the value of N-terminal pro-B-type natriuretic peptide(NT-proBNP)、results of echocardiogram and life quality score.By collecting these datas and work on a group of analysis ，investigators evaluate whether differences exsit in ACS patients with ejection <45% between participants who take vericiguat regularly and those who donot.

Inclusion criteria

• 1.Provide written informed consent for the trial.
• 2.Has acute coronary syndrome (unstable angina, non-ST elevation myocardial infarction [NSTEMI], or ST elevation myocardial infarction [STEMI]) or coronary revascularization (coronary artery bypass grafting [CABG] or percutaneous coronary intervention [PCI]).
• 3.ejection fraction <45%.
• 4.Be male or female, aged greater than18 and less than 90 on the day of signing informed consent.

Exclusion criteria

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• 1.SBP<100mmHg.
• 2.Is pregnant or breastfeeding or plans to become pregnant or to breastfeed during the course of the trial.
• 3.Has severe hepatic insufficiency or renal insufficiency.
• 4.Has malignancy or other non-cardiac condition limiting life expectancy to <1 years.