Skip to main content
OpenTrials
Completed

NCT Number: NCT01879488

Effect of Ventilation Mode on Lung Deposition of a Radiolabeled Aerosol During Mechanical Ventilation: Barometric Versus Volumetric

Controlling the respiratory pattern of mechanically ventilated patients in volume control mode is recommended during nebulization. No studies looked into conditions of nebulization during assisted mechanical ventilation to define the optimal nebulization technique and its effect on pulmonary deposition.

The aim of this study is to analyse the effect of ventilation mode (barometric versus volumetric) on deposition by planar scintigraphy during mechanical ventilation.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Post-operative Neurosurgery

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Cliniques Universitaires Saint-Luc

Brussels, 1200, Belgium

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Invasive mechanical ventilation
  • Healthy lungs

Exclusion criteria

  • Change of ventilation mode during nebulization

Treatment and study plan

Technetium-99m - Diethylenetriaminepentaacetic acid

Drug

Vibrating-mesh nebulizer

Device

Gamma Scintigraphy

Other

Preoperative spirometry

Other

Primary outcomes

  1. Pulmonary deposition

    Time frame: Immediately after nebulization by imaging assessment, an expected average of 30 minutes

Secondary outcomes

  1. Penetration index

    Time frame: Immediately after nebulization by imaging assessment, an expected average of 30 minutes

  2. Mechanical ventilation settings

    Time frame: During nebulisation time, an expected average of 15 minutes

  3. Lung function

    Time frame: Preoperative assessment, the day before inclusion

Sponsors and collaborators

Lead sponsor

Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Other

Registry information

Important dates

Study start
2013
Primary completion
2015
Study completion
2015
First posted
Jun 17, 2013
Registry last updated
Nov 17, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.