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Completed

NCT Number: NCT02401113

Effect of Ursolic Acid of Loquat Extract on Function of Muscle

This randomized, placebo-controlled, double-blind study was designed to investigate the efficacy and tolerability of Ursolic Acid of Loquat Extract for treatment of muscle function improvement with relatively health adults. 54 subjects received 500 mg of Loquat Extract per day or a placebo for 12 weeks.

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Key information

Conditions

Sarcopenia Atrophy Muscular Atrophy Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

19 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2 / Phase 3

About this study

This randomized, placebo-controlled, double-blind study was designed to investigate the efficacy and tolerability of Ursolic Acid of Loquat Extract for treatment of muscle function improvement with relatively health adults. 54 subjects received 500 mg of Loquat Extract per day or a placebo for 12 weeks. Change over time in muscle fuction was evaluated by four outcomes: assessment of appendicular skeletal mass using DEXA (dual energy X-ray absorptiometry); quadriceps muscle power by Biodex; hand grib power; and Short Physical Performance Battery, SPPB.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • BMI 18.5-30KG/M2

Exclusion criteria

  • > SERUM creatinine 1.2mg/dL
  • > AST or ALT 60IU/L
  • DM Patients

Treatment and study plan

UA group

Dietary Supplement

Ursolic Acid of Loquat Extract, 500mg/ day during 12 weeks

Primary outcomes

  1. quadriceps muscle function

    Time frame: 12weeks

Secondary outcomes

  1. ASM(appendicular skeletal mass) marker

    Time frame: 12weeks

  2. Short Physical Performance Battery, SPPB

    Time frame: 12weeks

Sponsors and collaborators

Lead sponsor

Pusan National University Hospital

Other

Registry information

Official study title

Effect of Ursolic Acid of Loquat Extract on Function of Muscle in Human

Important dates

Study start
2014
Primary completion
2015
Study completion
2015
First posted
Mar 27, 2015
Registry last updated
Nov 3, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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