Effect of Type-A Botulinum Toxin in the Post-radiosurgical Neck Contractures

Inclusion criteria

• Patients from 18 to 75 years old;
• malignant Tumor of aerodigestive ways, in forgiveness;
• Treatment containing the external radiotherapy ended since > 6 months
• Life expectancy > 6 months;
• patient complaining from cervical spasms with functional disability;
• Negative Pregnancy test;
• Women under effective contraception;
• Patients benefiting from a national insurance scheme;
• Patient having given a written consent.

Exclusion criteria

• Cervico-facial Surgery with reconstruction by pedicled flap
• Implantable Chamber with catheter in the internal jugular vein near the spasm;
• Muscular, neurological Pathology or malformative pulling a disorder of perception of the pain, an amyotrophy, a muscular weakness affecting the cervical axis or the upper limbs;
• Disorder generalized by the muscular activity (ex myasthenia);
• Cervical osseous or muscular Pathology pulling pains and disability before the beginning of the treatment (cervical degenerative osteoarthritis diagnosed to the cervical radiography, the slipped disc);
• Previous cervical injection of botulinum toxin ;
• Local Infection at the level of one of the sites proposed for injection;
• Histories of epilepsy;
• Patients presenting a hypersensitivity to the botulinum neurotoxin A or in one of its excipients;
• Patients under anticoagulation therapy, Under antibiotic treatment by aminoglycosides or amino 4 quinoline, under myorelaxant treatment or that must undergo an intervention with curarisation;
• Patients for whom a surgical operation is planned in the zone interested in the treatment
• Pregnant or breast-feeding Women;
• Patients for whom questionnaires will not be assessable (handicaps of communication, patient not speaking French, etc.).