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NCT Number: NCT07599254

Effect of Two Different Irrigation Protocols and Activation Techniques on Postoperative Pain in Single-visit Endodontic Retreatment: Prospective Randomized Clinical Trial

The relationship between different root canal irrigation techniques and pain after root canal treatment

Recruiting

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Key information

Conditions

Apical Periodontitis Jaw Diseases Mouth Diseases Periapical Diseases Periapical Periodontitis Periodontal Diseases Periodontitis Stomatognathic Diseases

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • o Patients aged 18-60 years who are classified as medically healthy (ASA I or II),
  • Mature, single-rooted and canal teeth that had root canal treatment at least four years ago,
  • Teeth with previous root canal obturation 2-4 mm short of the apex,
  • Teeth that do not need periodontal and prosthetic treatment and whose periapical index score (PAI) is between 2 and 4 ,
  • Teeth with single root and canal diagnosed with asymptomatic apical periodontitis,
  • Teeth suitable for rubber dam isolation.

Exclusion criteria

  • o Patients who had taken analgesics, antibiotics, or corticosteroids within two weeks before root canal retreatment,
  • Teeth exhibiting periodontal attachment loss,
  • Presence of vertical root fractures, external root resorption, or perforations,
  • Teeth with retained broken instruments,
  • Non-restorable teeth,
  • Patients in the pregnancy and breastfeeding period.

Treatment and study plan

root canal irrigation

Drug

Root canal irrigation and postoperative pain

Primary outcomes

  1. Evaluation of the relationship between different root canal irrigation techniques and post-canal treatment pain using surveys.

    Time frame: 3-5 month

Study contacts

Contact information is provided by the study sponsor or research team.

İPEK E ERASLAN AKYÜZ

CONTACT

[email protected]

+905385591409

Sponsors and collaborators

Lead sponsor

TC Erciyes University

Other

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
May 20, 2026
Registry last updated
May 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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