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Completed

NCT Number: NCT02148536

Effect of Transjugular Intrahepatic Portosystemic Shunt on Oxygenation in Cirrhotic Patients With Hepatopulmonary Syndrome

To prospectively investigate the effect of transjugular intrahepatic portosystemic shunt (TIPS) on oxygenation in cirrhotic patients with hepatopulmonary syndrome (HPS).

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Key information

Conditions

Hepatopulmonary Syndrome Digestive System Diseases Liver Diseases Lung Diseases Respiratory Tract Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

West China Hospital, Sichuan university

Chengdu, Sichuan, 610041, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Presence of cirrhosis
  • Alveolar-arterial oxygen gradient ≥ 15 mm Hg (≥ 20 mm Hg for age > 64 years)
  • Positive contrast-enhanced echocardiography

Exclusion criteria

  • Age of less than 18 years
  • Intrinsic cardiopulmonary disease
  • Malignancy
  • Active infection
  • Pregnancy
  • Previous shunt therapy
  • Refusal to participate

Treatment and study plan

Transjugular intrahepatic portosystemic shunt

Procedure

Primary outcomes

  1. Alveolar-arterial oxygen gradient (PA-a,O2)

    Time frame: 12 Weeks

Secondary outcomes

  1. Macroaggregated albumin (MAA) shunt fraction

    Time frame: 12 Weeks

  2. Exhaled nitric oxide (eNO)

    Time frame: 12 Weeks

Sponsors and collaborators

Lead sponsor

West China Hospital

Other

Registry information

Important dates

Study start
2014
Primary completion
2015
Study completion
2015
First posted
May 28, 2014
Registry last updated
Aug 31, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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