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NCT Number: NCT07354607

Effect of Transcutaneous Electrical Stimulation on Peripheral Blood Flow

The goal of this clinical trial is to learn if transcutaneous electrical nerve stimulation can affect blood flow in healthy volunteers. The main question it aims to answer is:

Determine the stimulation parameters (frequency in the range 5- 100Hz and proximal or distal placement) inducing the most significant hyperaemic response in volunteers.

Participants will attend to one visit ( 1h30) , 6 protocol of stimulation will be tested on his arm . If his agree, an optionnal measure will be made during another visit. During this optionnal visit, two modalities of intensity adjustment will be tested in regard of the result of the first part of the study.

Recruiting

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Key information

Conditions

Volunteer Adult

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Subject aged 18 years or older
  • Having freely given written consent, after being informed of the purpose of the study, its conduct and its risks.
  • Affiliated with a social security scheme

Exclusion criteria

  • Persons with pacemakers or any other implantable electrical devices,
  • Pregnant women
  • Suffering from dermatological conditions or muscle/skin lesions on the arms and forearms.
  • Participant unable to give free and informed consent.
  • Participant unable to comply with the specific procedures of the study.
  • Participant deprived of liberty or benefiting from legal protection measures.

Treatment and study plan

Transcutaneous Electrical Nerve Stimulation

Other

transcutaneous electrical nerve stimulation on arm. 6 different protocol will be apply testing different modality of frequency and positionnement of electrodes

Primary outcomes

  1. stimulation parameters that induce the most significant hyperaemic response

    Time frame: from enrollment to the end of the procedure (1h30)

    Determine the stimulation parameters (frequency in the range 5- 100Hz and proximal or distal placement) that induce the most significant hyperaemic response in volunteers.

Secondary outcomes

  1. Assess the score on a scale of disconfort level during stimulation for each condition

    Time frame: during testing procedure

    The outcome will be assess using a visual analogic disconfort scale ranging from 0 (no disconfort) to 10 (the highest disconfort imaginable).

  2. Compare stimulation intensities between each condition

    Time frame: during testing procedure

  3. Compare muscle metabolic demand between each condition

    Time frame: during testing procedure

Other outcomes

  1. ancillary : Compare blood flow kinetics during long-term stimulation (1 hour) according to the modalities of intensity adjustment over time (no adjustment vs. adjustment).

    Time frame: during testing procedure (second visit)

  2. ancillary : Compare the comfort reported by participants during long-term stimulation based on the methods used to adjust intensity over time (no adjustment vs. adjustment).

    Time frame: during testing procedure (second visit)

Study contacts

Contact information is provided by the study sponsor or research team.

leo blervaque

CONTACT

[email protected]

+33 4 79 96 59 10

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Metropole Savoie

Other

Collaborators

  • Laboratoire Interuniversitaire de Biologie de la Motricité
  • Université Savoie Mont Blanc

Registry information

Official study title

Effect of Transcutaneous Electrical Stimulation on Peripheral Blood Flow - a Pilot Study

Acronym: VASC-STIM

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jan 21, 2026
Registry last updated
Mar 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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