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NCT Number: NCT06548711

Effect of Transcutaneous Acupoint Electrical Stimulation (TAES) on Postoperative Cough in Lung Cancer

Observation and exploration of the improvement in cough symptoms in postoperative lung cancer patients with Transcutaneous Acupoint Electrical Stimulation (TAES), the change in Cough Symptom Score (CSS) compared to baseline, the change in Visual Analog Scale (VAS) score for cough symptoms compared to baseline, the change in total score of Leicester Cough Questionnaire-Mandarin Chinese version (LCQ-MC) compared to baseline, and overall evaluation of treatment effectiveness by patients. A total of 84 postoperative lung cancer patients with cough were strictly selected according to the inclusion/exclusion criteria and treated and followed up according to the research plan requirements. Clinical observation forms were completed and clinical data were recorded in the database. Statistical analysis was performed on relevant clinical observation indicators to report research results and write related papers.

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Key information

Conditions

Postoperative Cough Lung Cancer Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine

Tianjin, Tianjin Municipality, 300193, China

Location status: Recruiting

Location contact

Fanming Kong, PhD

CONTACT

[email protected]

+ 86 22 27986525

About this study

To obtain sufficient evidence from evidence-based medicine, prospective, random, blind, and controlled clinical trials are adopted to evaluate the effectiveness and safety of TEAS in treating postoperative cough in lung cancer patients. This study aims to provide a potential non-pharmacological treatment option for postoperative cough patients with lung cancer, improve the quality of life of postoperative lung cancer patients, identify the population that is more likely to benefit from TEAS treatment and provide a solid scientific basis and guidance for personalized acupuncture treatment for postoperative cough in lung cancer patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age between 18 and 80 years old - Surgery performed under general anesthesia for radical resection of lung cancer or lung cancer resection combined with lymph node dissection.
  • Pathological confirmation of primary lung cancer after surgery.
  • Duration of persistent dry cough after lung surgery ≥2 weeks.
  • Consciousness, ability to express opinions clearly, and voluntary signing of informed consent.

Exclusion criteria

  • Patients diagnosed with acute respiratory system diseases within 1 month.
  • Patients diagnosed with pneumonia based on chest X-ray.
  • Patients with a history of asthma or tuberculosis.
  • Patients with uncontrolled hyperthyroidism, severe hypertension, heart disease, systemic infection, coagulation disorders (hypercoagulable state or bleeding tendency), or other severe systemic diseases.
  • Patients who have used steroid drugs within the past 3 months.
  • Patients who have taken angiotensin-converting enzyme inhibitors (ACEIs) within the past 6 months.
  • Patients with surgical incisions, skin allergies, wounds, or infections in the treatment area.
  • Patients who cannot tolerate transcutaneous acupoint electrical stimulation or withdraw during the procedure.
  • Patients with contraindications to transcutaneous electrical stimulation or implanted electrophysiological devices.
  • Patients who are pregnant or breastfeeding.

Treatment and study plan

Transcutaneous Acupoint Electrical Stimulation (TAES)

Other

Transcutaneous acupoint electrical stimulation (TAES) is a non-invasive treatment method that delivers gentle electrical pulses through the skin to specific acupuncture points on the body. This technique aims to mimic the effects of traditional acupuncture, providing a convenient and painless method of treatment.

Primary outcomes

  1. LCQ-MC

    Time frame: Prior to treatment (baseline), at the end of treatment (week 2), and 2 weeks after the end of treatment (week 4)

    The questionnaire consists of 19 items, each of which is divided into 7 levels according to the severity, including the impact of chronic cough on the physiological domain (chest pain, cough, sputum, fatigue, sleep, hoarseness, etc.), psychological domain (feeling embarrassed, anxious, depressed, annoyed, etc.), and social domain (work, daily life, leisure activities, conversation, phone calls, interference with friends or family members). The score for each domain is the total score of each item in that domain divided by the number of questions (scored from 1 to 7), and the total score is the sum of the scores for the three domains (scored from 3 to 21). A higher score represents a better patient's health condition.

Study contacts

Contact information is provided by the study sponsor or research team.

Fanming Kong, PhD

CONTACT

[email protected]

+ 86 22 27986525

Sponsors and collaborators

Lead sponsor

Kong Fanming

Other

Registry information

Official study title

Director of Oncology Department, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Aug 12, 2024
Registry last updated
Sep 8, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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