Skip to main content
OpenTrials
Completed

NCT Number: NCT01027546

Effect of Tranexamic Acid on Reducing Postoperative Blood Loss in Cervical Laminoplasty

The purpose is to evaluate the efficacy of tranexamic acid in cervical laminoplasty; the surgical procedure used was identical in all cases.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Cervical Myelopathy

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Tranexamic acid, an inhibitor of fibrinolysis, has proven to be effective in reducing perioperative blood loss in patients undergoing total hip and knee arthroplasty. However, limited numbers of well-controlled trials in spinal surgery have been conducted due to heterogeneity in the performed surgical procedures.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients who were scheduled to undergo cervical laminoplasty from C3 to C6 for cervical multilevel compressive myelopathy with a narrow spinal canal for which nonoperative therapy had failed.

Exclusion criteria

  • Patients with chronic renal failure, cirrhosis of the liver, serious cardiac disease, allergy to TXA, a history of thromboembolic disease, and bleeding disorders, as well as those who were currently receiving antiplatelet and/or anticoagulant drugs, were excluded from this study.

Treatment and study plan

Tranexamic Acid

Drug

Administer 15 mg/kg body weight of tranexamic Acid mixed in 100 mL saline intravenously over 15 min before the skin incision

Primary outcomes

  1. perioperative blood loss

    Time frame: during and after surgery

Sponsors and collaborators

Lead sponsor

Yodakubo Hospital

Other

Registry information

Important dates

Study start
2007
Primary completion
2008
Study completion
2008
First posted
Dec 8, 2009
Registry last updated
Dec 8, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.