Effect of Traditional Chinese Medicine of Severe COVID-19

In this study, a multi center randomized controlled trial design was adopted, and the subjects were randomly divided into the experimental group and the control group. The control group was treated with western medicine conventional treatment plus traditional Chinese medicine decoction simulant, while the experimental group was treated with traditional Chinese medicine syndrome differentiation treatment decoction. The course of treatment was 14 days and the patients were followed up for 3 months. The clinical effect of integrated traditional Chinese and Western medicine treatment was evaluated from the aspects of 28 day mortality, 28 days without invasive mechanical ventilation, invasive mechanical ventilation rate, 28 days without ICU stay, clinical stability time, length of hospital stay, quality of life, SOFA score, etc., to clarify the clinical efficacy of integrated traditional Chinese and Western medicine treatment for Severe COVID-19 infection.

Inclusion criteria

• accord with the diagnosis of severe/critical novel coronavirus infection;
• Age > 18 years old;
• TCM syndrome differentiation diagnosis by the attending physician or above or two attending physicians for diagnosis and consensus;
• Sign the informed consent form.

Exclusion criteria

• Pregnant and lactating women;
• Trauma, hematological malignancies, various solid tumors and obstetric complications;
• Dementia, various mental patients and those who are unwilling to cooperate;
• The patient is expected to die within the next 24 hours;
• Combined with neuromuscular diseases affecting respiratory and motor functions;
• people who have been bedridden for a long time for various reasons;
• Clinical trial participants who are taking part in other intervention measures;
• Those who are known to be allergic to the therapeutic drugs in this study.