Skip to main content
OpenTrials
Completed

NCT Number: NCT07748585

Effect of Titanium-Prepared Platelet-Rich Fibrin and Low-Level Laser Therapy on Postoperative Morbidity After Mandibular Third Molar Surgery

This randomized double-blind clinical trial aims to evaluate the effects of titanium-prepared platelet-rich fibrin (T-PRF), low-level laser therapy (LLLT), and their combination on postoperative outcomes following surgical extraction of impacted mandibular third molars. Sixty patients will be randomly allocated to one of four parallel groups: T-PRF, LLLT, T-PRF plus LLLT, or control. The primary outcomes include postoperative pain assessed using a visual analogue scale (VAS), analgesic consumption, postoperative swelling and trismus. The findings may help identify effective approaches for improving postoperative recovery after mandibular third molar surgery.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Impacted Mandibular Third Molar Extraction

Age range

18 year–31 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Cyprus Health and Social Sciences University, Faculty of Dentistry

Güzelyurt, 99700, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults requiring surgical extraction of a unilateral vertically impacted mandibular third molar.
  • Healthy individuals (ASA I or II).
  • Ability to provide written informed consent.
  • Willingness to attend all follow-up visits.

Exclusion criteria

  • Systemic disease affecting wound healing.
  • Pregnancy or lactation.
  • Active infection or acute pericoronitis.
  • Long-term opioid use.
  • Smoking and alcohol use.
  • Known allergy to study medications.
  • Previous radiotherapy to the head and neck region
  • Inability to attend follow-up visits.

Treatment and study plan

Titanium-Prepared Platelet-Rich Fibrin (T-PRF)

Procedure

Titanium-prepared platelet-rich fibrin (T-PRF) was prepared from autologous blood and placed into the extraction socket immediately after mandibular third molar surgery.

Low-level laser therapy (LLLT)

Device

Low-level laser therapy was applied using a 650 nm diode laser (25 mW) immediately after surgery and once daily for the following two postoperative days.

Primary outcomes

  1. Postoperative Pain

    Time frame: Postoperative Days 1, 2, 3, and 7

    Postoperative pain assessed using a 100-mm Visual Analog Scale (VAS).

  2. Analgesic Consumption

    Time frame: Postoperative Days 1, 2, 3, and 7

    Number of analgesic tablets consumed after surgery.

  3. Facial Swelling

    Time frame: Preoperative baseline and Postoperative Days 1, 2, 3, and 7

    Postoperative facial swelling will be evaluated using standardized linear facial measurements. Three distances will be measured with a flexible measuring tape: tragus to the corner of the mouth (Tragus-Commissure), tragus to the soft-tissue pogonion (Tragus-Pogonion), and lateral canthus of the eye to the mandibular angle (Lateral Canthus-Gonion). The sum of the three measurements (in centimeters) will be recorded for each participant. Higher values indicate greater postoperative facial swelling.

  4. Maximum Interincisal Mouth Opening (Trismus)

    Time frame: Preoperative baseline and Postoperative Days 1, 2, 3, and 7

    Postoperative trismus will be evaluated by measuring the maximum interincisal mouth opening using a calibrated ruler. The distance (in millimeters) between the incisal edges of the maxillary and mandibular central incisors during maximum mouth opening will be recorded for each participant. Lower values indicate greater postoperative trismus.

Sponsors and collaborators

Lead sponsor

NEW Cyprus Health and Social Sciences University

Other

Registry information

Official study title

Effects of Titanium-Prepared Platelet-Rich Fibrin and Low-Level Laser Therapy on Postoperative Pain, Swelling, Trismus, and Analgesic Consumption Following Mandibular Third Molar Surgery: A Randomized Double-Blind Clinical Trial

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Aug 5, 2026
Registry last updated
Aug 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.