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OpenTrials
Completed

NCT Number: NCT01690884

Effect of Ticagrelor vs. Dipyridamole on Adenosine Uptake

The investigators are trying to determine if a single dose of Ticagrelor will increase delivery of intraarterially-infused adenosine into the forearm interstitium, consistent with adenosine reuptake blockade.

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Key information

Conditions

Coronary Artery Disease Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Coronary Disease Heart Diseases Myocardial Ischemia Vascular Diseases

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

Autonomic Dysfunction Center

Nashville, Tennessee, 37232, United States

About this study

The investigators will compare adenosine interstitial levels using a parallel design study with three groups of subjects. Forearm interstitial adenosine levels will be measured at baseline and after intrabrachial infusion of adenosine at two doses. Subjects will then randomly receive Ticagrelor 180 mg, Dipyridamole 200 mg, or placebo. Two hours later the investigators will repeat the dialysate collections at baseline and after adenosine infusions.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Subjects will be healthy volunteers, without significant pulmonary, cardiovascular gastrointestinal, hematological or renal diseases
  • Not taking any regular medications
  • Able to provide signed consent prior to study participation.

Exclusion criteria

  • History of asthma
  • Pregnancy
  • Exposure to an investigational drug in the last 2 months.
  • Known hypersensitivity to study medications

Treatment and study plan

Adenosine

Drug

Adenosine will be infused into the brachial artery at 0.125 mg/min for 15 minutes and then at 0.5 mg/min for an additional 15 minutes,

Other names: Adenocard

Primary outcomes

  1. Interstitial levels of adenosine

    Time frame: After each dose of intrabrachial adenosine

Sponsors and collaborators

Lead sponsor

Vanderbilt University

Other

Registry information

Official study title

Ticagrelor and Adenosine Uptake. Phase II Study Comparing the Effects of Ticagrelor vs Dipyridamole on Adenosine Uptake

Important dates

Study start
2012
Primary completion
2017
Study completion
2017
First posted
Sep 24, 2012
Registry last updated
Feb 28, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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