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NCT Number: NCT06341049

Effect of Three Different Postcesarean Analgesic Techniques on QbsQor-10 Score

The aim of this study is to evaluate the effects of three different postsesarean analgesia techniques, including instillation of local anesthetic into the peritoneum with infiltration into all layers of the anterior abdominal wall, intrathecal morphine injection with local anesthetic, and quadrotus lumborum type 1 block, on the postoperative recovery of women using the ObsQoR-10 score..

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Key information

Conditions

Postoperative Recovery

Age range

18 year–50 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Ataturk University

Erzurum, Palandoken, Turkey (Türkiye)

About this study

This study will be planned on women who will undergo elective cesarean section surgery with neuraxial anesthesia, after obtaining ethics committee approval and written informed consent from the patients.Parturients will be randomized by the statistician using a computerized random numbers table and divided into 3 equal groups: Group IPLA + LWI, Group QLB 1 and Group M.Postoperatively, patients' ObsQoR-10 scores will be evaluated and recorded at the 24th and 48th hours.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Elective cesarean section under spinal anesthesia
  • Full-term singleton pregnancy
  • Agree to participate in the study
  • American Society of Anaesthesiology Score of II

Exclusion criteria

  • Contrindication for neuraxial anesthesia
  • ASA≥3, diabetes, preeclampsia, cardiovascular disease, chronic pain and neuropathic pain
  • Age< 18 or > 50
  • Multiple pregnancy
  • Presence of psychiatric diseases
  • Gave a history of allergic to any medication in the study protocol
  • Gave a history of chronic pain
  • Unable to consent
  • BMI>35 kg/m2
  • Those who were given opioids during the operation due to intraoperative pain
  • Those who have had previous abdominal surgery
  • Patients who failed spinal anesthesia and switched to general anesthesia
  • Those who have excessive bleeding or uterine atony during the operation
  • Does not understand VAS
  • Those who have a drain placed in the area to be infiltrated
  • Gave a history of drug addiction

Treatment and study plan

Intraperitoneal local anasthetic application + local anesthetic wound infiltration

Procedure

For Group Intraperitoneal local anasthetic+ loal anesthetic wound infiltration, after the birth of the newborn and placenta, the uterus is taken out and closed, the blood accumulated in the pelvis is carefully wiped with surgical towels, and after complete hemostasis is achieved, sterilely prepared 20 ml 0.5% bupivacaine + 20 ml 2% lidocaine +1 A total of 40 ml of solution containing 200,000 epinephrine will be given to the surgeon. 10 ml of this solution will be instilled into all four quadrants of the uterus before closing the parietal peritoneum or fascia. The parietal peritoneal layer will be sutured or left open, depending on the surgeon's preference. 10 ml will be infiltrated around the edges of the rectus aponeurosis, and the remaining 20 ml will be infiltrated subcutaneously into the wound area.

Intrathecal morphine application

Procedure

Group Morphine will be given 11.2 mg hyperbaric bupivacaine + 15 µg fentanyl + 150 µg morphine into the spinal space.

Quadratus lumborum block tip 1 application

Procedure

In Group Quadratus lumborum block, Quadratus lumborum block type I, a total of 40 ml of a solution containing 20 ml of 0.5% bupivacaine + 20 ml of 2% lidocaine + 1:200,000 epinephrine will be applied bilaterally under ultrasound guidance.

Primary outcomes

  1. obstetric quality of recovery-10 (ObsQoR-10) scores of parturient at the 24th and 48th postoperative hours

    Time frame: Postoperative 24th and 48th hours

    For post-cesarean analgesia, patients will receive instillation of local anesthetic into the peritoneum with infiltration into all layers of the anterior abdominal wall, intrathecal morphine injection with local anesthetic, and quadrotus lumborum type 1 block. ObsQoR-10 scores of the patients will be evaluated at the 24th and 48th hours postoperatively.

Sponsors and collaborators

Lead sponsor

Ataturk University

Other

Registry information

Official study title

Effect of Three Different Postcesarean Analgesic Techniques on ObsQoR-10 Score: Prospective, Randomized Trial

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Apr 2, 2024
Registry last updated
Nov 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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