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Completed

NCT Number: NCT01251081

Effect of the Intensity of Continuous Renal Replacement Therapy

In patients with sepsis and AKI, increasing the intensity of renal replacement therapy from 50 mL/kg/h (HVHF) to 85 mL/kg/h (EHVHF)will increase the survival at 28 days and 90 days.

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Key information

Conditions

Optimal Intensity of Renal Replacement Therapy on Sepsis Patients Acute Kidney Injury Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Infections Inflammation Kidney Diseases Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Sepsis Systemic Inflammatory Response Syndrome Urogenital Diseases Urologic Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Kidney disease center, the first affiliated hospital, medical college of Zhejiang university

Hangzhou, Zhejiang, 310003, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

met at least one of the following criteria: oliguria (urine output less than 100 mL in a 6 h period and unresponsive to fluid resuscitation), serum potassium concentration more than 6.5 mmol/L, severe acidemia (pH < 7.2), serum creatinine more than 250 µmol/L, or presence of severe organ edema (e.g. pulmonary edema).

Exclusion criteria

  • were presence of a malignant tumor, chronic renal insufficiency (serum creatinine >133 µmol/L), or receiving any kind of renal replacement therapy before randomization.

Treatment and study plan

extra high volume hemofiltration

Other

extra high volume hemofiltration (85 mL/kg/h, EHVHF)

high volume hemofiltration

Other

high volume hemofiltration (50 mL/kg/h, HVHF)

Primary outcomes

  1. 90 days survival

    The primary study outcome was death from any cause within 90 days. Results were analyzed by Kaplan-Meier survival curves

Secondary outcomes

  1. length of stay in the ICU and hospital

    Secondary outcomes were length of stay in the ICU and hospital and renal outcome of survivors at 90 days after randomization.

Sponsors and collaborators

Lead sponsor

Zhejiang University

Other

Registry information

Official study title

Effect of the Intensity of Continuous Renal Replacement Therapy in Patients With Sepsis and Acute Kidney Injury: Single-center Randomized Clinical Trial

Important dates

Study start
2004
Primary completion
2009
Study completion
2010
First posted
Dec 1, 2010
Registry last updated
Dec 1, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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