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OpenTrials
Completed

NCT Number: NCT00900913

Effect of Systemic Ropivacaine on Hyperalgesia, Flare Reaction and Peripheral Nerve Excitability

The purpose of this study is to compare the effect of intravenous ropivacaine and lidocaine on the receptive field of primary sensory afferents and their influence on the vascular bed.

*Trial with medicinal product

Completed

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Key information

Conditions

Healthy Volunteers

Age range

18 year–65 year

Sex eligibility

Male

Study type

Interventional

Phase

Phase 4

Primary location

Clinical Trial Center

Zurich, Switzerland

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male
  • Age: 18 - 65 years
  • Weight: 50-100kg
  • Height: 155-195cm
  • Signed and dated informed consent
  • Sufficient command of German language

Exclusion criteria

  • Contraindications to the class of drugs under study
  • Vulnerable subjects (intellectually or mental impaired)
  • Known hypersensitivity to class of drugs or the investigational product
  • Drug abuse
  • Known peripheral neuropathies
  • Diabetes mellitus
  • Chronic alcohol consumption
  • Congestive heart disease
  • Participants of other studies during study period
  • Smoker

Treatment and study plan

ropivacaine (Naropin)

Drug

intravenous infusion 1 mg/kg bw

Other names: Naropin

Primary outcomes

  1. Aera of flare reaction (cm2), area of primary and secondary hyperalgesia (cm2)

    Time frame: 1 year

Sponsors and collaborators

Lead sponsor

University of Zurich

Other

Registry information

Official study title

Effect of Systemic Ropivacaine on Hyperalgesia, Flare Reaction and Peripheral

Important dates

Study start
2010
Primary completion
2011
Study completion
2011
First posted
May 13, 2009
Registry last updated
Aug 8, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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