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Completed

NCT Number: NCT00409123

Effect of Systemic Cooling in Vasospasms

This study tests whether women with Vasospastic Syndrome (VS) react more intensive than controls with distal vasomotions and choroidal blood flow changes to internal cooling/warming and external cooling/warming.

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Key information

Conditions

Vasospastic Syndrome

Age range

19 year–35 year

Sex eligibility

Female

Study type

Observational

Primary location

University Eye Clinic

Basel, 4056, Switzerland

About this study

Distal vasomotions and choroidal blood flow changes to internal cooling/warming and external cooling/warming was studied in VS and controls.Core cooling was induced by drinking of 250g ice/water mixture (4°C). Core warming was induced by drinking of 250g warm water (55°C). The study was controlled with respect to posture and room temperature.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • women
  • luteal phase or contraceptives
  • 19-35 years

Exclusion criteria

  • somatic diseases
  • psychiatric diseases
  • BMI > 25
  • BMI < 18

Treatment and study plan

Primary outcomes

  1. LDF blood flow

    Time frame: repeated after each challenge

  2. LDF velocity

    Time frame: repeated after each challenge

  3. finger skin temperature

    Time frame: repeated after each challenge

  4. core body temperature

    Time frame: repeated after each challenge

  5. corneal temperature

    Time frame: repeated after each challenge

Secondary outcomes

  1. subjective sleepiness

    Time frame: repeated after each challenge

  2. subjective ratings of thermal comfort

    Time frame: repeated after each challenge

Sponsors and collaborators

Lead sponsor

University Hospital, Basel, Switzerland

Other

Registry information

Official study title

Effect of Systemic Cooling in Vasospasms (Kühleffekte Beim Vasospastischen Syndrom)

Important dates

Study start
2004
Primary completion
2006
Study completion
2006
First posted
Dec 8, 2006
Registry last updated
Sep 26, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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