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Completed

NCT Number: NCT00759005

Effect of Stress on Heroin-Related Memory Retrieval

The purpose of this study is to determine whether cortisol and propranolol are effective in the modulation of stress induced heroin-related retrieval enhancement.

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Key information

Conditions

Heroin Dependence Chemically-Induced Disorders Learning and Memory Mental Disorders Narcotic-Related Disorders Opioid-Related Disorders Substance-Related Disorders

Age range

20 year–40 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

National Institute on Drug Dependence

Beijing, Beijing Municipality, 100191, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Participants had to have met DSM-IV criteria for heroin dependence prior to abstinence.

Exclusion criteria

  • current use of any medications; current DSM-IV diagnosis of any affective, anxiety, or psychotic disorder; current dependence on any substance besides heroin and nicotine (based on DSM-IV criteria); or risk factors for untoward side effects from propranolol and cortisol (i.e., irregular heartbeats, history of cardiogenic shock, history of severe heart failure, asthma, fungal Infections, hyperlipidemia, history of hypertension, or abnormal ECG or other laboratory findings).

Treatment and study plan

propranolol and cortisol

Drug

Primary outcomes

  1. Glucocorticoids enhanced heroin-related memory retrieval in abstained heroin addicts

Sponsors and collaborators

Lead sponsor

National Institute on Drug Dependence, China

Other

Registry information

Important dates

Study start
2007
Primary completion
2008
Study completion
2008
First posted
Sep 25, 2008
Registry last updated
Sep 25, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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