Skip to main content
OpenTrials
Completed

NCT Number: NCT02619019

Effect of Spinal Dexamethasone During Transuretheral Prostatectomy

Dexamethasone, a high-potency, long-acting glucocorticoid, when added to bupivacaine, it extended the duration of analgesia. We aim to study the effectiveness of spinal dexamethasone in Transuretheral prostatectomy.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Postspinal Shivering

Age range

50 year–75 year

Sex eligibility

Male

Study type

Interventional

Phase

Phase 2

Primary location

Seham Mohamed Moeen Ibrahim

Asyut, Asyut Governorate, 71111, Egypt

About this study

Spinal anesthesia for endoscopic urology surgery like transurethral resection of the prostate is a well-established technique. Opioids are extensively used as an adjunct to local anesthetics in neuraxial blockade to enhance the duration of postoperative analgesia. However, worrisome adverse effects like pruritus, urinary retention, postoperative vomiting and respiratory depression limit its use. The aim of this study was to investigate the effectiveness of Intrathecal dexamethasone as adjunct to local anesthetics.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age: 50-75 yr ASA class I,II, and III undergoing Transuretheral prostatectomy under spinal anesthesia

Exclusion criteria

  • Contraindications to spinal anesthesia, Allergy to the study medication, Thyroid disease, Parkinson's disease Patients receiving vasodilators or medications likely to alter thermoregulation.

Treatment and study plan

Dexamethasone

Drug

Patients will receive 8 mg of hyperbaric bupivacaine 0.5%, plus 8 mg of dexamethasone intrathecally

Pethidine

Drug

Patients will receive 8 mg of hyperbaric bupivacaine 0.5%, plus 0.2 mg/kg of pethidine intrathecally

Other names: Mepredine

normal saline

Drug

Patients will receive 8 mg of hyperbaric bupivacaine 0.5%, plus 2 ml normal saline intrathecally

Primary outcomes

  1. Shivering

    Time frame: 150 min after spinal anesthesia

    by shivering score

Secondary outcomes

  1. Mean arterial blood pressure

    Time frame: 150 min after spinal anesthesia

    immediately before the block and then every 15 min after the block

  2. Heart rate

    Time frame: 150 min after spinal anesthesia

    immediately before the block and then every 15 min after the block

  3. Core temperature

    Time frame: 150 min after spinal anesthesia

    immediately before the block and then every 15 min after the block

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Intrathecal Dexamethasone in Patients Undergoing Transuretheral Prostatectomy.

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
Dec 2, 2015
Registry last updated
Sep 15, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.