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Completed

NCT Number: NCT07400822

Effect of Sour Taste on Swallowing Function of Patients With Dysphagia After Acute Ischemic Stroke

This randomized controlled study was designed to determine the Effect of Sour Taste on Swallowing Function of Patients with Dysphagia After Acute Ischemic Stroke The study was conducted between july 2021 and november 2022 with 95 patients diagnosed with Acute Ischemic Stroke (47 intervention, 48 control) at the neurology clinic and outpatient clinic of a university hospital in Edirne. Data were collected using the Personal Information Form, the Gugging Swallowing Screening Test (GUSS), and the National Institutes of Health Stroke Scale (NIHSS).

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Key information

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Trakya University Medical Research and Application Centre

Edirne, Center, 22030, Turkey (Türkiye)

About this study

This study was designed to evaluate the effect of sour taste on swallowing function of patients who developed dysphagia after ischemic stroke.The study sample consisted of patients (n=95) diagnosed with ischemic stroke and had impaired swallowing function hospitalized in a neurology clinic of a university hospital. Patients in the intervention group were given 4 ml of lemon juice (pH=2.8) at room temperature before breakfast, lunch, and dinner, while patients in the control group were given 4 ml of water at room temperature at the same time periods. Patients' swallowing function and stroke severity were assessed on the 7th and 30th days. Data were collected using the Personal Information Form, the Gugging Swallowing Screening Test (GUSS), and the National Institutes of Health Stroke Scale (NIHSS).

Financial Support:The present study was supported by the Research Fund of Trakya University. Project No:2021/214

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Hospitalized with a confirmed diagnosis of ischemic stroke
  • Within the first 72 hours after diagnosis
  • Developed dysphagia
  • Who could understand and cooperate
  • Patients who volunteer signed an informed consent

Exclusion criteria

  • Patients with cerebral hemorrhage or other neurologic disorders
  • Patients with severe stroke and high NIHSS scores
  • Who were likely to experience severe dysphagia
  • Patients who do not volunteer to participate in the study

Treatment and study plan

sour taste

Other

Sour taste stimulation using freshly squeezed lemon juice administered orally.

Control

Other

Room-Temperature Water Administration

Primary outcomes

  1. Gugging Swallowing Screen score

    Time frame: one month

    Change in the mean scores of the Gugging Swallowing Screen (GUSS) score of the patients at the first interview, on the 7th day and on the 30th day

  2. National Institutes of Health Stroke Scale score

    Time frame: one month

    Change in the mean scores of the National Institutes of Health Stroke Scale (NIHSS) of the patients at the first interview, on the 7th day and on the 30th day

Sponsors and collaborators

Lead sponsor

AYFER GUNES

Other

Collaborators

  • Trakya University

Registry information

Official study title

İnme Sonrası Yutma Bozukluğu Gelişen Hastalara Erken Dönemde Verilen Ekşi Sıvının Yutma Fonksiyonu Üzerine Etkisinin Değerlendirilmesi

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Feb 10, 2026
Registry last updated
Jun 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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