Effect of Sleep Disorder on the Development of Lung Tumors

The goal of this observational study is to observe the lung tumor development in lung tumor patients with long-term sleep disorder. The main questions it aims to answer are:

* will long-term sleep disorder promote the malignancy of lung tumor * if so, how exactly will the microenvironment of lung tumor change Participants will receive PSQI scale and MRI functional brain imaging before surgery, blood and tumor tissue will be collected during the surgery.

Researchers will set non-sleep disorder group as control group to see if lung tumor microenvironment change when long-term sleep disorder exists in lung tumor patiens.

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Key information

Conditions

Sleep Disorder, Lung Tumor Lung Diseases Lung Neoplasms Mental Disorders Neoplasms Neoplasms by Site Nervous System Diseases Neurologic Manifestations Pathological Conditions, Signs and Symptoms Respiratory Tract Diseases Respiratory Tract Neoplasms Signs and Symptoms Sleep Wake Disorders Thoracic Neoplasms

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

18-75 years old
elective sublobectomy for primary lung tumor
ASA grade I-II
Informed consent of the patient or family

Exclusion criteria

Combination of serious heart, liver, kidney, central nervous system, blood system, immune system diseases or serious mental illness
Combination of other cancers
untreated active lung infection
patients with preoperative neoadjuvant radiotherapy

Treatment and study plan

Primary outcomes

tumor microenvironment in sleep-disordered lung cancer patients

Time frame: 3 months after surgery

we use single cell sequencing to analyze microenvironment alterations of tumor tissues in enrolled patients.

Secondary outcomes

peripheral blood levels of neurotransmitters in sleep-disordered lung cancer patients

Time frame: 3 months after surgery

peripheral blood levels of epinephrine, noradrenaline, 5-HT in sleep-disordered lung cancer patients
Functional brain imaging in sleep-disordered lung cancer patients

Time frame: 3 months after surgery

Functional brain imaging

Study contacts

Contact information is provided by the study sponsor or research team.

Weifeng Yu

CONTACT

[email protected]

13901961704

Yumiao Shi

CONTACT

[email protected]

19821850236

Sponsors and collaborators

Lead sponsor

RenJi Hospital

Other

Registry information

Official study title

Effect of Sleep Disorder on the Development of Lung Tumors, a Perspective, Single-centered Study

Important dates

Study start: 2023
Primary completion: 2026
Study completion: 2026
First posted: Feb 27, 2023
Registry last updated: Feb 27, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed