Effect of Simethicone on Bowel Preparation for Colonoscopy

• Study design: endoscopist-blinded, prospective, randomized controlled trial
• Subjects

• A single-center, randomized, observer-blinded study was performed at Korea University Hospital in Anam. Outpatients were prospectively enrolled. Each group of the patients will receive PEG-Asc or PEG-Asc with simethicone before colonoscopy.
• Sampling design: Consecutive recruitment of consenting patients
• Variables Predictor

• group 1 (PEG-Asc) received 1 L solution of PEG-Asc at 7 p.m the evening before colonoscopy and another 1 L solution of PEG-Asc at 5 hours before procedure;
• group 2 (PEG-Asc with simethicone) received 1 L solution of PEG-Asc at 7 p.m the evening before colonoscopy and another 1 L solution of PEG-Asc at 5 hours before procedure;Two packs (200 mg/10 mL each) of simethicone (400 mg) was mixed with last 500 mL of additional clear fluid.
• Primary Outcome: Quality of bowel preparation [Boston Bowel Preparation Scale, bubble score]
• Secondary Outcome: Patients and endoscopists' compliance[Tolerability, palatability of patient, fatigue score of endoscopist]

Inclusion criteria

• Male or female patients,
• aged between18 and 80 years undergoing elective outpatient colonoscopy were eligible for the study

Exclusion criteria

• patients who had chronic kidney disease,
• severe heart failure(New York Heart Association [NYHA] class III or IV)
• uncontrolled hypertension (systolic pressure ≥170 mm Hg, diastolic pressure ≥100 mm Hg)
• severe constipation
• any bowel resection
• significant gastroparesis, or
• suspected bowel obstruction or perforation.