University Hospital Zurich, Division of Pneumology
Zurich, Canton of Zurich, 8091, Switzerland
Completed
NCT Number: NCT01748474
Effect of Short-term Oxygen During CPET in Pulmonary Hypertension
In a randomized, sham-controlled trial the investigators will test whether supplemental oxygen given during cardiopulmonary exercise testing will improve exercise performance and physiological parameters in patients with pulmonary arterial or chronic thromboembolic pulmonary hypertension.
Completed
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Notify MeKey information
Conditions
Age range
20 year–80 year
Sex eligibility
All sexes
Study type
Interventional
Phase
Phase 2
Primary location
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- diagnosis of pulmonary arterial hypertension class I and IV (according to the latest WHO classification scheme of Dana Point 2008)
- on optimized medical therapy and in stable condition for at least 4 week
- desaturate in the 6 minute walking test by at least 4% to values <92%
Exclusion criteria
- unstable conditions
- pregnant women
- patients with pulmonary venous hypertension
- patients with relevant concomitant lung disease and severe daytime hypoxemia
Treatment and study plan
Supplemental oxygen via a mask
ProcedurePrimary outcomes
-
Watt
Time frame: 1 day
-
exercise time
Time frame: 1 day
Secondary outcomes
-
Peak oxygen uptake
Time frame: 1 day
-
Respiratory exchange ratio
Time frame: 1 day
-
ventilatory equivalent of carbon dioxide (VE/VCO2) slope
Time frame: 1 day
-
end-tidal pressures of carbon dioxide (PET CO2)
Time frame: 1 day
-
Changes in arterial blood parameters
Time frame: 1 day
Sponsors and collaborators
Lead sponsor
University of Zurich
Other
Registry information
Official study title
Effect of Short-term Oxygen Therapy on Cardiopulmonary Exercise Capacity in Patients With Pulmonary Arterial and Chronic Thromboembolic Pulmonary Hypertension
Acronym: ExOx-CPET
Important dates
- Study start
- 2012
- Primary completion
- 2016
- Study completion
- 2016
- First posted
- Dec 12, 2012
- Registry last updated
- Aug 12, 2016
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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