Konya City Hospital
Konya, 42020, Turkey (Türkiye)
Location status: Recruiting
Recruiting
NCT Number: NCT07295158
Effect of Sevoflurane vs Desflurane on Mechanical Power in Laparoscopic Cholecystectomy
This single-center, prospective, randomized, assessor-blinded clinical trial aims to compare the effects of sevoflurane and desflurane anesthesia on intraoperative mechanical power in adult patients undergoing elective laparoscopic cholecystectomy. Mechanical power will be measured at three standardized time points using a validated formula, and secondary outcomes include driving pressure values and early postoperative respiratory complications (desaturation, laryngospasm, bronchospasm, cough).
Recruiting
Interested in participating?
Request InfoKey information
Conditions
Age range
18 year–65 year
Sex eligibility
All sexes
Study type
Interventional
Phase
Not applicable
Primary location
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Adults aged 18-65 years
ASA Physical Status I-II
Scheduled for elective laparoscopic cholecystectomy
Able to provide written informed consent
Exclusion criteria
Known hypersensitivity or contraindication to study medications (sevoflurane or desflurane)
Severe chronic obstructive pulmonary disease (COPD)
Uncontrolled bronchial asthma
Decompensated heart failure (NYHA Class III-IV)
History of prior lung surgery
Morbid obesity (BMI > 35 kg/m²)
Pregnancy
Refusal to participate or inability to provide informed consent
-
Treatment and study plan
Sevoflurane
DrugGeneral anesthesia will be maintained with sevoflurane at 2% concentration in patients assigned to the Sevoflurane Group (Group S). Standardized ventilator settings will be applied for all participants, and mechanical power will be measured at three intraoperative time points while sevoflurane is used as the sole maintenance inhalational agent.
Other names: Group S
Desflurane
DrugMaintenance of general anesthesia with desflurane 6% during laparoscopic cholecystectomy. Mechanical power is measured at three intraoperative time points using standardized ventilator settings.
Primary outcomes
-
Mechanical Power (MP) during General Anesthesia
Time frame: Measured at three intraoperative time points: Post-intubation baseline (MP1) 15 minutes after pneumoperitoneum (MP2) End of surgery before emergence (MP3)
Study contacts
Contact information is provided by the study sponsor or research team.
Sponsors and collaborators
Lead sponsor
Konya City Hospital
Other
Registry information
Official study title
Laparoscopic Cholecystectomy Patients: Effect of Sevoflurane vs. Desflurane on Mechanical Power - A Prospective, Randomized, Controlled Trial
Acronym: VAPOR
Important dates
- Study start
- 2026
- Primary completion
- 2026
- Study completion
- 2026
- First posted
- Dec 19, 2025
- Registry last updated
- Jul 20, 2026
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.