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Completed

NCT Number: NCT02506972

Effect of Serving Size and Addition of Sugar on the Glycemic Response Elicited by Oatmeal

The purpose of this study was to determine the impact of serving size and the addition of sugar on the glycemic response elicited by oatmeal compared to that elicited by cream of rice cereal.

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Key information

Conditions

Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Glycemic Index Laboratories, Inc.

Toronto, Ontario, M5C 2N8, Canada

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • body mass index (BMI) 20.0 - 34.9 kg/m²

Exclusion criteria

  • known to have diabetes
  • use of medications considered by the principal investigator to influence glycemic responses

Treatment and study plan

Classic Quaker Quick Oats

Other

Various doses of oats without or with sugar

Cream of Rice Cereal

Other

Various doses of cereal without sugar

Primary outcomes

  1. Incremental area under the blood glucose response curve

    Time frame: For 2 hours after consuming each test meal

Secondary outcomes

  1. Peak rise of blood glucose

    Time frame: During 2 hour period after consuming each test meal

    The highest concentration of blood glucose achieved after eating minus the fasting blood glucose.

  2. Time to peak

    Time frame: During 2 hour period after consuming each test meal

    The time at which the peak rise of blood glucose occured.

  3. Mean rate of decline in blood glucose

    Time frame: During 2 hour period after consuming each test meal

    The rate of change in blood glucose between consecutive time points (Tx and T(x+1)) was calculated as: Rx = (Gx G(x+1))/(Tx-T(x+1)), where G(x+1) and Gx were the glucose concentrations at times T(x+1) and Tx, respectively. The mean rate of decline in blood glucose (Mean RD) was calculated as the weighted average of all the Rx values from the time of the peak glucose concentration to 120 min, with the weight based on the length of the time interval.

  4. Maximum rate of decline in blood glucose

    Time frame: During 2 hour period after consuming each test meal

    The rate of change in blood glucose between consecutive time points (Tx and T(x+1)) was calculated as: Rx = (Gx G(x+1))/(Tx-T(x+1)), where G(x+1) and Gx were the glucose concentrations at times T(x+1) and Tx, respectively. . The maximum rate in blood glucose decline (Max RD) was calculated as the maximum of all the Rx values from the time of the peak glucose concentration to 120 min.

  5. Time to baseline

    Time frame: During 2 hour period after consuming each test meal

    The time for blood glucose to return to baseline was linearly interpolated between the first blood glucose concentration below fasting and the previous value; if blood glucose did not reach baseline, Bt was taken to be 120min.

Sponsors and collaborators

Lead sponsor

Glycemic Index Laboratories, Inc

Industry

Collaborators

  • Applied Statistics and Consulting
  • PepsiCo Global R&D

Registry information

Official study title

Effect of Varying Amounts of β-glucan and Sucrose in Oatmeal on Glycemic Response

Acronym: Panther

Important dates

Study start
2013
Primary completion
2014
Study completion
2014
First posted
Jul 23, 2015
Registry last updated
Jul 23, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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